| A Case of Hypocomplementemic Henoch-Schönlein Purpura Presenting Features of Membranoproliferative Glomerulonephritis |
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Kyong-A Lee, Tae-Sun Ha |
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Department of Pediatrics, College of Medicine, Chungbuk National University, Cheongju, Korea |
| 저 보체 혈증 및 막성 증식성 사구체 신염의 임상 상을 보인 Henoch-Schölein (Purpura) Nephritis 1례 |
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이경아, 하태선 |
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충북대학교 의과대학 소아과학교실 |
Correspondence:
Tae-Sun Ha, Email: tsha@chungbuk.ac.kr
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| Abstract |
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Henoch-Schönlein purpura (HSP) is a systemic disorder characterized by leukocytoclastic vasculitis that can affect multiple organs predominantly the skin, joints, gastrointestinal tract and kidney. Although the specific pathogenesis of HSP is not known, there are several hypotheses. Although the importance of the complement activation in glomerular injury in HSP has been suggested, the complement levels and the blood pressure in those patients are usually normal and massive proteinuria is not common. And pathologic renal changes also have been reported to show a large variety of glomerular changes. However, to our knowledge, a membranoproliferative glomerulo-nephritis (MPGN) is a rare renal clinicopathologic manifestation of HSP. We report a 6-year-old boy with HSP who developed MPGN with hypertension, massive proteinuria, and hypo-complementemia revealed activation of the classical complement pathway, although we could not exclude the possibility of other hypocomplementemic glomerulonephritis including post-streptococcal acute glomerulonephritis. |
| Key Words:
Henoch-Schö, nlein purpura, Hypocomplementemic glomerulonephritis, membranoproliferative glomerulonep |
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