| Expression of Nerve Growth Factor during Urinary Bladder Development |
|
Kyoung Eun Lee1, Chang Hee Hong2, Hee Jung Kang3, Dug Ha Kim1 |
1Department of Pediatrics, College of Medicine, Hallym University, Chuncheon, Korea
2Department of Urology, College of Medicine, Hallym University, Chuncheon, Korea
3Department of Laboratory Medicine, College of Medicine, Hallym University, Chuncheon, Korea |
| 방광 발달과정에서 Nerve Growth Factor의 발현 |
|
이경은1, 홍창희2, 강희정3, 김덕하1 |
1한림대학교 의과대학 소아과학교실
2한림대학교 의과대학 비뇨기과학교실
3한림대학교 의과대학 진단검사의학교실 |
Correspondence:
Dug Ha Kim, Email: dougkim@hallym.or.kr
|
|
|
|
|
| Abstract |
Purpose
: This study was performed to determine the developmental expression pattern of nerve growth factor(NGF) in the urine of healthy children. It was hypothesized that NGF may contribute to the development of the spinobulbospinal micturition reflex that represents the adult micturition pattern.
Methods
: Voided urine was collected in 60 healthy children during the first 5 years of life(0-1 month, n=10; 1 month-1 year, n=10; 2 years, n=10; 3 years, n=10; 4 years, n=10). The urinary NGF was analyzed by using an enzyme linked immunosorbent assay. Results were normalized based on creatinine or total protein in urine.
Results
: NGF was significantly greater among neonates compared to other age groups(P<0.05). NGF levels declined during 1 month to 1 year and increased by age 2 years. NGF levels at age 3 years were less than in neonates examined. When comparing the NGF levels according to continence in children over 1 year old, NGF levels were significantly lower in children with continence than in children with incontinence(P<0.05).
Conclusion
: These data suggest that NGF is involved in the achievement of continence and in mechanisms of bladder nerve growth and in the reorganization of bladder reflex pathway. |
| Key Words:
Nerve growth factor , Development , Urinary bladder |
|
PDF Links
Download Citation
