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Endogenous Neurogenesis in Postnatal Brain

Korean Journal of Pediatrics 2005;48(8):806-812.
Published online August 15, 2005.
Endogenous Neurogenesis in Postnatal Brain
Yun Sil Chang
Department of Pediatrics, Samsung Medical Center, Sungkyunkwan Universtiy School of Medicine, Seoul, Korea
출생 후 뇌의 내인성 신경세포 생성
성균관대학교 의과대학 삼성서울병원 소아과
Yun Sil Chang, Email: yschang@smc.samsung.co.kr
Repair mechanisms in the postnatal and mature central nervous system(CNS) have long been thought to be very limited. However recent works have shown that the mature CSN contains neural progenitors, precursors, and stem cells that are capable of generating new neurons, astrocytes, and oligodendrocytes especially in germinative areas such as the subventricular zone of the lateral ventricles, the dentate gyrus of the hippocampus. These findings raise the possibilities for the development of novel neural repair strategies via mobilization and replacement for dying neurons of neural stem cells in situ. Indeed recent reports have provided evidences that endogenous stem cells are activated in response to various injuries, and in some injury models, limited neuronal replacement occurs in the CNS. Here, current understandings for endogenous neurogenesis and induction neurogeneis in postnatal CNS including neonatal brain are summarized and discussed.
Key Words: Endogenous , Neural stem cell , Induction neurogenesis , Newborn , Adult

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