| Serum Ferritin as a Risk Factor in Type 2 Diabetes Mellitus |
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Jung Hyun Kim, Ho Seong Kim, Duk Hee Kim |
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Department of Pediatrics, College of Medicine, Yonsei University, Seoul, Korea |
| 2형 당뇨병 발생위험인자로서의 혈청 Ferritin의 의의 |
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김정현, 김호성, 김덕희 |
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연세대학교 의과대학 소아과학교실 |
Correspondence:
Duk Hee Kim, Email: dhkim3@yumc.yonsei.ac.kr
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| Abstract |
Purpose
: Iron accumulation interferes with hepatic insulin extraction and affects insulin synthesis and secretion. The purpose of this study is to investigate the correlation between serum ferritin and type 2 diabetes mellitus.
Methods
: We compared the serum ferritin level among 18 patients in an impaired glucose tolerance (IGT) group, 36 in a type 1 diabetes group, eight in a type 2 diabetes group and 29 in a healthy control group. The correlation between serum ferritin levels and sex, body mass indices(BMI), blood pressure(BP), serum fasting sugar level and serum fasting insulin level were also analyzed.
Results
: The mean log ferritin were 1.33?.32(healthy control group), 1.63?.19(IGT group) and 1.90?.30(type 2 diabetes group). In the IGT group, log ferritin was higher than in the healthy control group(P=0.001). The log ferritin of the type 2 diabetes group was higher than that of the healthy control group(P=0.001). Comparing log ferritin to other factors, log ferritin had a significant positive correlation with body mass indices(P<0.001), systolic blood pressure(P=0.001), and fasting glucose(P= 0.001), fasting insulin(P=0.002).
Conclusion
: Compared to the normal healthy group, serum ferritin concentrations were significantly higher in the IGT group and the type 2 diabetes group. The elevation of serum ferritin concentration may be a risk factor of type 2 diabetes mellitus. |
| Key Words:
Serum ferritin , Type 2 diabetes mellitus , Insulin resistance syndrome |
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