| The efficacy of ketogenic diet in childhood intractable epilepsy with malformation of cortical development |
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Young-Mock Lee1, Du Cheol Kang2, Da Eun Chung3, Hoon Chul Kang3, Heung Dong Kim1 |
1Department of Pediatrics, Institute for Handicapped Children, Yonsei University College of Medicine
2Department of Pediatrics, Changwon Fatima Hospital, Cangwon
3Department of Pediatrics, Epilepsy Center, Sang-gye Paik Hospital, Inje University College of Medici |
| 대뇌 피질 발달 기형을 동반한 난치성 소아 간질에서 케톤생성 식이요법의 효과 |
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이영목1, 강두철2, 정다은3, 강훈철3, 김흥동1 |
1연세대학교 의과대학 소아과학교실
2창원파티마병원 소아과
3인제대학교 의과대학 상계백병원 소아과, 간질센터 |
Correspondence:
Heung Dong Kim, Email: hdkimmd@yumc.yonsei.ac.kr
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| Abstract |
Purpose
: Malformation of cortical development(MCD) constitutes an important etiology of intractable epilepsy and is considered an indication for surgical treatments, though their efficacy is limited and variable depending on MCD's location or distribution. Ketogenic diets are widely known to be effective, but as little study has been made concerning their efficacy on epilepsy with MCD, we evaluated the efficacy of ketogenic diets on MCD patients compared with that of epileptic surgery, which is more invasive.
Methods
: We performed retrospective studies and analyse on 30 patients with MCD diagnosed by brain MRI and treated with ketogenic diets for intractable epilepsy since 1998, checking decreases in their seizure episodes after starting the diets.
Results
: Cortical dysplasia was observed in 24(80.0 percent) patients as the most common type of MCD. Also, MCD was observed in unilateral hemisphere most commonly, in 23(76.7 percent) patients; it was observed in both hemispheres in 7(23.3 percent) patients. Nine(30.0 percent) out of 30 patients became seizure-free after starting ketogenic diets, and 14(46.7 percent) patients experienced 50 percent seizure reductions as well. Age of starting the diet or the duration of epilepsy period before starting showed no statistical relationship with the efficacy of the diet. Though the younger the patient and the longer the treatment the more effective the diet seemed to be, there was no statistical correlation between them. The location of MCD showed no significance neither.
Conclusion
: Considering various limits and invasiveness of surgical treatment, a ketogenic diet could be a good tool in treating children with intractable epilepsy with MCD. |
| Key Words:
Malformation of cortical development , Cortical dysplasia , Ketogenic diet , Epilepsy |
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