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Polymorphisms of the CTLA-4 promoter(-318) and exon 1(+49) genes with atopic dermatitis in Korean children

Korean Journal of Pediatrics 2006;49(5):545-551.
Published online May 15, 2006.
Polymorphisms of the CTLA-4 promoter(-318) and exon 1(+49) genes with atopic dermatitis in Korean children
Tae Won Song, Hea Sun Yang, Kyung Eun Lee, Kyung Won Kim, Eun Soo Kim, Myung Hyun Sohn, Kyu-Earn Kim, M.D
Department of Pediatrics and Institute of Allergy, BK21 Project for Medical Science, Yonsei Universi
아토피피부염 환아에서 CTLA-4 exon 1과 promoter 유전자 다형성
송태원, 양혜선, 이경은, 김경원, 김은수, 손명현, 김규언
연세대학교 의과대학 소아과학교실 및 알레르기 연구소, 두뇌한국21 의과학사업단
Correspondence: 
Myung Hyun Sohn, Email: mhsohn@yumc.yonsei.ac.kr
Abstract
Purpose
: The gene-encoding cytotoxic T lymphocyte-associated antigen-4(CTLA-4) is one of the candidate genes for conferring susceptibility to atopic dermatitis(AD). The aim of the study was to investigate the association between Korean children with AD and the polymorphisms of CTLA-4 gene promoter(-318) and exon 1(+49).
Methods
: The CTLA-4 promoter(-318 T/C) and exon 1(+49 A/G) polymorphisms were genotyped via restriction fragment length polymorphism methods in 145 children with atopic eczema, 69 children with non-atopic eczema, and 96 healthy controls.
Results
: There was no significant difference in genotype and allele frequencies of the CTLA-4 promoter -318 T/C and exon 1 +49 A/G polymorphisms when the atopic eczema, non-atopic eczema, and control groups were compared. Additionally the CTLA-4 promoter -318 T/C and exon 1 +49 A/G polymorphisms were not shown to be associated with severity, IgE level, or eosinophil counts.
Conclusion
: Our data show that the polymorphisms within the CTLA-4 promoter(-318 T/C) and exon 1(+49 A/G) genes are not associated with susceptibility to AD in Korean children.
Key Words: Atopic dermatitis , CTLA-4 , Polymorphism


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