Korean Journal of Pediatrics 2006;49(6):630-634.
Published online June 15, 2006.
A study of the current(2003-2005) prevalence of anti-HBs and immunologic memory of hepatitis B vaccine in children from the central area of Korea
Young Won An1, Eun Hee Chung1, Insoo Rheem2
1Department of Pediatrics, College of Medicine, Dankook University, Cheonan, Korea
2Department of Laboratory Medicine, College of Medicine, Dankook University, Cheonan, Korea
최근(2003-2005) 우리나라 중부지역 소아에서 B형 간염 항체 보유율과 백신의 면역학적 기억에 대한 연구
안영원1, 정은희1, 임인수2
1단국대학교 의과대학 소아과학교실
2단국대학교 의과대학 진단검사의학교실
Correspondence: 
Eun Hee Chung, Email: ehchung@dankook.ac.kr
Abstract
Purpose
: This study was conducted to assess the current(2003-2005) prevalence of anti-HBs and immunologic memory for Hepatitis B vaccine in children from the central area of Korea.
Methods
: Subjects were chosen from children and adolescents who received tests for hepatitis B surface antigen(HBsAg) and anti-HBs at Dankook University Hospital from March 2003 to May 2005. Among these, antibodies to hepatitis B core antigen(IgG anti-HBc) were checked. A single booster vaccination was performed on children whose anti-HBs titers were under 10 mIU/mL. One month after booster vaccination we rechecked the anti-HBs titer.
Results
: A total of 3,277 subjects were tested for HBsAg/anti-HBs, and 1,913(58.4 percent) of them were positive for anti-HBs. Of these, 29 subjects(0.9 percent) were positive for HBsAg. Positive results for anti-HBs by age were 78.6 percent for 6-12 months of age, 62.7 percent for 1-3 years of age, 51.9 percent for 4-6 years of age, 49.5 percent for 7-12 years of age, 63.4 percent for 13-15 years of age and 72.2 percent for 16-18 years of age. The 80 subjects who were tested negative for HBsAg/anti-HBs received a single booster vaccine, 71 subjects were tested positive for antibodies. IgG anti-HBc titer was checked for 169 of the subjects, 5 subjects were positive.
Conclusion
: In our study, a significant anamnestic response was observed in 88.8 percent of children. This is believed to be a result of the relatively long immunologic memory effect of the hepatitis B vaccination in children from the central area of Korea.
Key Words: Hepatitis B vaccine , Booster vaccination , Immunologic memory


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