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Analysis of cow's milk specific IgE positive patients in newborns

Korean Journal of Pediatrics 2006;49(10):1061-1066.
Published online October 15, 2006.
Analysis of cow's milk specific IgE positive patients in newborns
Gil Sang Lee, Nam Kyung Baek, Won Duck Kim
Department of Pediatrics, Fatima Hospital, Daegu, Korea
신생아에서 우유 특이 IgE 항체검사 양성을 보인 환아에 대한 분석
이길상, 백남경, 김원덕
대구파티마병원 소아과
Correspondence: 
Won Duck Kim, Email: neogubugi@yahoo.co.kr
Abstract
Purpose
: The purpose of this study was to research whether measurement of cow's milk specific IgE on the newborn would be helpful in the diagnosis of cow's milk allergy. We tried to find out the relation between cow's milk specific IgE and other allergy diseases by following up cases.
Methods
: We reviewed clinical features of 87 episodes in infants less than 4 weeks old who were positive in cow's milk specific IgE test. For the study group, history taking, physical examinations, elimination and cow's milk specific IgE tests were carried out. We investigated the connection among cow' milk specific IgE, allergic disease and family history in 40 of 87 patients we could follow up on.
Results
: The mean age of the study group was 17.2±5.4 days. The subjects were classified in four groups according into allergens : 87 milk allergy positive patients, 24 casein positive, 38 α-lactoalbumin positive, and 75 β-lactoglobulin positive. The number of patients who had follow-ups for more than 6 months to was 40(45.9 percent). The patients whose parents had allergic disease numberred 10(25 percent). Fiften patients had allergic diseases, 4 had asthma and 11 atopic dermatitis. According to the follow-up study, there is a significant relation between casein positive patients and allergic disease. But there is no statistical and significant relation between cow's milk specific IgE and a family history of allergic disease.
Conclusion
: For the newborn babies, elimination tests and cow's milk specific IgE tests can be useful in the diagnosis of IgE-mediated or mixed milk allergies.
Key Words: Newborn , Milk allergy , Immunoglobulin E


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