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Clinical factors causing hyperbilirubinemia in patients with Kawasaki disease

Korean Journal of Pediatrics 2007;50(1):52-55.
Published online January 15, 2007.
Clinical factors causing hyperbilirubinemia in patients with Kawasaki disease
Kyung Hee Moon, Ok Ran Kim, Seung Taek Yu, Myung Eun Hong, Chang Woo Lee, Du Young Choi, Yeon Kyun Oh, Jong Duk Kim, Hyang Suk Yoon
Department of Pediatrics, Wonkwang University School of Medicine, Iksan, Korea
가와사끼병에서 고빌리루빈혈증의 관련인자에 대한 임상적 고찰
문경희, 김옥란, 유승택, 홍명은, 이창우, 최두영, 오연균, 김종덕, 윤향석
원광대학교 의과대학 소아과학교실
Correspondence: 
Hyang Suk Yoon, Email: dyhs0520@wonkwang.ac.kr
Abstract
Purpose
: Hyperbilirubinemia, jaundice and gallbladder hydrops are unusual manifestations of Kawasaki disease (KD). In this case, abdominal pain, anorexia and abdominal distension may follow eventfully. We reviewed the clinical and laboratory data to investigate the causative factors of hyperbilirubinemia in patients with KD.
Methods
: Two-hundred eighty two children diagnosed and hospitalized with KD were identified by searching patients' charts. Cases were included in the study if diagnosed between January 1997 and December 2004. We reviewed clinical data, age, sex, duration from the onset of fever to admission and duration from start of treatment to defervescence. Clinical and laboratory data were compared between normal (A) and hyperbilirubinemia (B) groups.
Results
: Thirteen patients (4.6 percent) showed hyperbilirubinemia. In the hyperbilirubinemia group, age and initial ALT value were higher than group A (P=0.003, 0.018 respectively). Duration from the onset of fever to admission and age were relative risk factors in hyperbilirubinemia (P=0.007, 0.003 respectively) in patients with KD.
Conclusion
: Shorter duration from the onset of fever to admission and older age group were relative risk factors of hyperbilirubinemia in patients with KD.
Key Words: Kawasaki disease , Hyperbilirubinemia


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