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Analysis of urine β2-microglobulin in pediatric renal disease

Korean Journal of Pediatrics 2007;50(4):369-375.
Published online April 15, 2007.
Analysis of urine β2-microglobulin in pediatric renal disease
Dong Woon Kim, In Seok Lim
Department of Medical Science, Graduate School of Medicine, Chung-Ang University, Seoul, Korea
소아 신장질환에서 요 β2-microglobulin검사의 분석
김동운, 임인석
중앙대학교 의과대학 소아과학교실
Correspondence: 
In Seok Lim, Email: inseok@cau.ac.kr
Abstract
Purpose
: There have been numerous researches on urine β2-microglobulin (β2-M) concerned with primary nephrotic syndrome and other glomerular diseases, but not much has been done in relation to pediatric age groups. Thus, our hospital decided to study the relations between the analysis of the test results we have conducted on pediatric patients and renal functions.
Methods
: Retrospective data analysis was done to 102 patients of ages 0 to 4 with renal diseases with symptoms such as hematuria, edema, and proteinuria who were admitted to Chung-Ang Yongsan Hospital and who participated in 24-hour urine and urine β2-M excretion test between January of 2003 and January of 2006. Each disease was differentiated as independent variables, and the statistical difference of the results of urine β2-M excretion of several groups of renal diseases was analyzed with student T-test by using test results as dependent variables.
Results
: Levels of urine β2-M excretion of the 102 patients were as follows : 52 had primary nephrotic syndrome [MCNS (n=45, 72±45 g/g creatinine, g/g-Cr), MPGN (n=3, 154±415 g/g-Cr), FSGS (n=4, 188±46 g/-Cr)], six had APSGN (93±404 g/g-Cr), seven had IgA nephropathy (3,414±106 g/g-Cr), 9 had APN (742±160 g/g-Cr), 16 had cystitis (179±168 g/g-Cr), and 12 had HSP nephritis (109±898 g/g-Cr). IgA nephropathy (P<0.05) and APN (P<0.05) were significantly higher than in other renal diseases. Among primary nephrotic syndrome, FSGS with higher results of β2-microglobulin test had longer treatment period (P<0.01) when compared to the lower groups, but no significant differences in Ccr, BUN, or Cr were observed.
Conclusion
: IgA nephropathy and APN groups showed significantly higher level of β2-M excretion value than other groups. Although β2-microglobulin value is not appropriate as an indicator of general renal function and pathology, it seems to be sufficient in the differential diagnosis of the UTI and in the prediction of the treat-ment period of nephrotic syndrome patients.
Key Words: Beta-2-microglobulin , Renal disease


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