| Antibody prsistence after Haemophilus influenzae type b (Hib)
primary vaccination and response to boosters in Korean children |
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Hyunju Lee1, So Eun Park2, Soo Young Lim3, Kyong Min Choi4, Hoan Jong Lee5, Kyung Hyo Kim1 |
1Department of Pediatrics, College of Medicine, Ewha Womans University, Seoul, Korea
2Department of Pediatrics, College of Medicine, Pochon Cha University, Seoul, Korea
3Department of Microbiology, College of Medicine, Ewha Womans University, Seoul, Korea
4Department of Pediatrics, College of Medicine, Kwandong University, Seoul, Korea
5Department of Pediatrics, College of Medicine, Seoul National University, Seoul, Korea |
| 한국 소아에서 Haemophilus influenzae type b (Hib) 기초 예방접종 후 항체 지속과 추가 접종에 대한 반응 |
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이현주1, 박소은2, 임수영3, 최경민4, 이환종5, 김경효1 |
1이화여자대학교 의과대학 소아과학교실
2포천중문 의과대학 소아과학교실
3이화여자대학교 의과대학 미생물학교실
4관동대학교 의과대학 소아과학교실
5서울대학교 의과대학 소아과학교실 |
Correspondence:
Kyung Hyo Kim, Email: kaykim@ewha.ac.kr
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| Abstract |
Purpose
: Antibody persistence after primary series of Haemophilus influenzae type b (Hib) vaccine and responses to boosters are seldom studied in Korean children. We performed this study to evaluate the antibody titer in relation to booster immunization of Hib vaccine in Korean children.
Method
: One hundred forty four children aged 12-23 months were enrolled in three university hospitals. The immunogenicity of boosters with Hib vaccine was assessed in children previously primed with Hib vaccine. Antibody persistence was also assessed in children who had received 3 doses of Hib vaccine without a booster. Anti-polyribosylribitol phosphate (PRP) IgG antibody levels and bactericidal titers were determined by enzyme immunoassay and bactericidal assay at the Center for Vaccine Evaluation and Study, Medical Research Institute, Ewha Womans University.
Results
: Prior to a booster in the second year of life, geometric mean antibody concentrations were 2.39 g/mL and the percent of subjects who had a anti-PRP antibody level 1 g/mL was 68.6%. After boosting, antibody concentration was 19.09 g/mL and the percent of subjects who had a anti- PRP antibody level 1 g/mL was 96.5%, which reflects previous immune priming. In subjects who had finished primary immunization only, the bactericidal titer was 3,946 and in subjects who had a booster, it was 11,205. Anti-PRP antibody level was correlated with serum bactericidal titer.
Conclusion
: Many children aged 12-23 month old still had protective antibodies after recommended primary immunization only. A booster dose seemed to induce good anamnestic antibody responses in Korean children. |
| Key Words:
Haemophilus influenzae type b, Antibodies, Immunization, Booster |
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