| Polymorphism in the promoter region of the plasminogen activator inhibitor-1 (PAI-1) gene in Kawasaki disease |
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Mi Young Han |
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Department of Pediatrics, College of Medicine, Kyunghee University, Seoul, Korea |
| 가와사키병 환아에서 plasminogen activator inhibitor-1 유전자 다형성에 관한 연구 |
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한미영 |
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경희대학교 의과대학 소아과학교실 |
Correspondence:
Mi Young Han, Email: myhan44@hanmail.net
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| Abstract |
Purpose
: To demonstrate genetic background of pathogenesis of Kawasaki disease (KD), I examined the genetic polymorphism of plasminogen activator inhibitor-1 (PAI-1) in KD patients.
Methods
: PCR-RFLP of PAI- 1 promotor gene was analyzed in 56 KD patients admitted to Kyunghee University Hospital, Gachon Medical School Gil Hospital, and Eulji Hospital from March to August 2000 and 206 normal control populations.
Results
: There were no differences in the genotype and allelic frequency of the PAI-1-675 (4G/5G) and PAI-1-844 (G/A) polymorphic site (which are located in the promoter region) between KD and control subjects. Also I could not detect any significant differences in specific genotypes between patients with the coronary artery lesion (CAL) and patients without CAL.
Conclusion
: No association was observed in -844 G/A and -675 4G/5G of PAI-1 gene polymorphism with KD. |
| Key Words:
Kawasaki disease, Genetic Polymorphsm, Plasminogen activator inhibitor |
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