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Maintenance dose of electrolyte free polyethylene glycol (PEG) 4000 in Korean children with chronic functional constipation

Korean Journal of Pediatrics 2007;50(12):1212-1216.
Published online December 15, 2007.
Maintenance dose of electrolyte free polyethylene glycol (PEG) 4000 in Korean children with chronic functional constipation
So Hee Lee, Sun Hwan Bae
Department of Pediatrics, School of Medicine, Konkuk University, Seoul, Korea
한국인 소아에서 만성 기능성 변비치료 시 전해질이 함유되지 않은 PEG 4000의 유지용량
이소희, 배선환
건국대학교 의학대학원 소아과학교실
Correspondence: 
Sun Hwan Bae, Email: baedori@hanafos.com
Abstract
Purpose
: To determine optimal maintenance dose and to evaluation the efficacy and safety of polyethylene glycol 4000 (PEG4000) in children with chronic functional constipation.
Methods
: This study enrolled 41 children with chronic functional constipation at the Konkuk university hospital August 2005, then June, 2007. Effective maintenance dose was designed as initial amount of PEG4000 that improved frequency, bowel movement, stool consistency for 2 months. Clinical outcome was analysed on the basis of defecation diary. Adverse effect was monitored clinically and biochemically.
Results
: As a whole group effective maintenance dose of PEG4000 was 0.55?.16 g/kg/day (0.25-0.86). With respect to age, 3-5 years (0.60?.15), 6-8 years (0.57?.16), 9-13 years (0.44?.14) (P=0.024). With respect to body weight, <30 kg (0.62?.14), 30 kg (0.41?.10) (P=0.001). One child comlained apigastric soreness on medication.
Conclusion
: PEG4000 is effective and safe in children with chronic constipation. Initial maintenance dose of PEG4000 was 0.55 g/kg/day.
Key Words: Polyethylene glycol 4000, Maintenance dose, Constipation, Child


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