| Change of neutrophil count after treatment of intravenous immunoglobulin in children with idiopathic thrombocytopenic purpura |
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Jun Young Park, Ji Ae Park, Seong Shik Park, Young Tak Lim |
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Department of Pediatrics, Pusan National University College of Medicine, Busan, Korea |
| 소아 특발혈소판감소자색반병에서 면역글로불린 투여 후 호중구수치의 변화 |
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박준영, 박지애, 박성식, 임영탁 |
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부산대학교 의과대학 소아과학교실 |
Correspondence:
Young Tak Lim, Email: limyt@pusan.ac.kr
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| Abstract |
Purpose
: The aim of this study was to investigate the incidence and course of neutropenia following intravenous immunoglobulin (IVIG) therapy in children with idiopathic thrombocytopenic purpura (ITP).
Methods
: From January 2001 to June 2006, fifty-four patients with ITP were enrolled in this study. Forty-two of 54 patients were treated with IVIG, while the other 12 were treated with anti-D immunoglobulin (Anti-D Ig). Post-treatment absolute neutrophil counts (ANC) were compared between patients who received IVIG and those who received Anti-D Ig. Comparison of post-treatment ANC between patients who treated with two different IVIG regimens (400 mg/kg/day for 5 days and 1 g/ kg/day for 2 days) was also performed.
Results
: Pretreatment ANC were not significantly different between the two treatment groups. After treatment with IVIG, 32 out of 42 patients (76.2%) showed more than 50% decrease of ANC from the baseline. On the other hand, only 2 out of 12 patients (16.7%) showed more than 50% decrease of ANC from the baseline after treatment Anti-D Ig. No significant difference was observed in the decline of ANC between the first IVIG treatment (42 patients) and repeated IVIG treatment groups (7 patients). There was no statistical difference in post-treatment ANC between patients who treated with two different IVIG regimens. The neutropenia induced by IVIG had resolved spontaneously in 38 out of 39 patients (97%) after several days.
Conclusion
: Neutropenia following IVIG administration may not be an uncommon finding in children with ITP. It seems to be transient and self limited. |
| Key Words:
Neutropenia, Intravenous immunoglobulin, Idiopathic thrombocytopenic purpura |
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