| Transforming growth factor-β gene promoter polymorphism : its association with
renal involvement in Henoch-Sch lein Purpura in childhood |
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Seung Ho Lee1, Hwa Young Jee1, Hwang Min Kim1, Byung Il Yeh2 |
1Department of Pediatrics, Wonju College of Medicine, Yonsei University, Wonju, Korea
2Department of Biochemistry, Wonju College of Medicine, Yonsei University, Wonju, Korea |
| 소아 Henoch-Sch lein purpura에서 전환성장인자-β 프로모터유전자의 유전학적 다형성과 신장침범의 관련성 |
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이승호1, 지화영1, 김황민1, 예병일2 |
1연세대학교 원주의과대학 소아과학교실
2연세대학교 원주의과대학 생화학교실 |
Correspondence:
Hwang Min Kim, Email: khm9120@yonsei.ac.kr
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| Abstract |
Purpose
: Several cytokines play important roles in the inflammatory process of Henoch-Sch lein Purpura (HSP). It is likely that transforming growth factor-β (TGF-β) is involved in the pathogenesis of HSP. The purpose of this study is to investigate whether TGF-β promoter polymorphism is associated with the renal involvement of childhood HSP.
Methods
: Thirty-four patients younger than 15 years, who had been diagnosed with HSP, as well as 27 controls, were examined. Patients and controls were genotyped for TGF-β C-509T by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).
Results
: The T allelic frequencies in patients and controls showed no difference (45% vs. 48.8%). No allele or genotype differences between the group of HSP group and control group were observed. The frequencies of TGF-β 509 genotypes TT, TC, and CC were no different between patients and controls (26% vs. 22%). The TT genotype of polymorphism of the TGF-β C-509T gene had no relation to the susceptibility of children to HSP and renal involvement in HSP.
Conclusion
: TGF-β T allele may not be related to the susceptibility of children to HSP. The TT genotype of polymorphism of the TGF-β C 509T gene does not appear to have an influence on renal involvement in childhood HSP. |
| Key Words:
Henoch-Sch lein Purpura, TGF-β polymorphism, Renal involvement |
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