| Relationship between cord blood level of IL-12 in
preterm newborns and development of wheezing |
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Hyo Jung Yu1, Eun Ae Park1, Ji Young Kim1, Soo Jin Cho1, Young Ju Kim2, Hye Sook Park3, Eun Hee Ha3 |
1Department of Pediatrics, Ewha Womans University, School of Medicine, Seoul, Korea
2Department of Obstetrics and Gynecology, Ewha Womans University, School of Medicine, Seoul, Korea
3Department of Preventive Medicine, Ewha Womans University, School of Medicine, Seoul, Korea |
| 34주 미만 미숙아 제대혈청 내 interleukin-12 농도와 영아기 천명 발생과의 관계 |
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유효정1, 박은애1, 김지영1, 조수진1, 김영주2, 박혜숙3, 하은희3 |
1이화여자대학교 의과대학 소아과학교실
2이화여자대학교 의과대학 산부인과학교실
3이화여자대학교 의과대학 예방의학과학교실 |
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| Abstract |
Purpose
: Abnormal activation patterns of Th1/Th2-cells have been suggested to increase the prevalence of allergic diseases. Prevention is regarded as an important corner stone in the management of allergic diseases. In this study, we have investigated the relationship between cord blood levels of IL-4, IL-10, and IL-12 in preterm newborns and the development of allergic respiratory diseases in infancy
Methods
: Forty-six preterm newborns born at the Ewha Womans University Mokdong Hospital between January 2003 and July 2005, were enrolled for this study, and consent was obtained to test their cord blood samples. Clinical history was obtained from the hospital records. Cord blood was obtained at birth and kept frozen until it was tested. The levels of IL-4, IL-10, and IL-12 were determined by enzyme-linked immunosorbent assay (ELISA).
Results
: All infants were followed-up for a median of 16.0 months?3.2 d (range, 12.0 to 36.0 months). Eighteen infants who developed wheezing showed lower cord blood levels of IL-12 (366.60?40.40 vs 435.09?1.20 pg/mL, P=0.009). Cord blood levels of IL-4 and IL-10 showed no significant difference between the two groups. Four newborns who later developed asthma, and infants with asthma showed lower IL-12 level in the cord blood than other groups.
Conclusion
: Lower concentration of cord blood levels of IL-12 in newborns who later developed wheezing and asthma suggested that they had abnormal activation patterns of Th1/Th2-cells at the time of birth, and cord blood IL-12 level can be used as a predictor of allergic respiratory diseases. |
| Key Words:
Cord blood, IL-12, Wheezing, Asthma, Preterm infant |
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