| Detection and clinical manifestations of twelve respiratory viruses in
hospitalized children with acute lower respiratory tract infections :
Focus on human metapneumovirus, human rhinovirus and human coronavirus |
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Kum Hyang Kim1, Jung Ho Lee1, Dong Shin Sun1, Dong Shin Sun2, Young Jin Choi3, Joon Soo Park1, Chang Jin Kim4, Dong Jun Jung4 |
1Department of Pediatrics, Soonchunhyang University Hospital, Soonchunhyang University School of Medicine, Cheonan, Korea
2Department of Preventive Medicine, Soonchunhyang University Hospital, Soonchunhyang University School of Medicine, Cheonan, Korea
3Department of Laboratory Medicine, Soonchunhyang University Hospital, Soonchunhyang University School of Medicine, Cheonan, Korea
4Department of Pathology‡, Soonchunhyang University Hospital, Soonchunhyang University School of Medicine, Cheonan, Korea |
| 하기도 감염으로 입원한 소아에서 12종 바이러스의 검출 및 임상 양상 |
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김금향1, 이정호1, 선동신1, 김용배2, 최영진3, 박준수1, 김창진4, 정동준4 |
1순천향대학교 의과대학 소아과학교실
2순천향대학교 의과대학 예방의학교실
3순천향대학교 의과대학 진단검사의학교실
4순천향대학교 의과대학 병리학교실 |
Correspondence:
Dong Jun Jung, Email: Juny1024@sch.ac.kr
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| Abstract |
Purpose
: This study was perfomed to analyze in detail the viral etiology of acute lower respiratory tract infections (ALRI) in Cheunan, Korea by multiplex RT-PCR, including human rhinovirus (hRV) and newly identified viruses such as human metapneumovirus (hMPV) and human coronavirus (HCoV-OC43, HCoV-229E/NL63).
Method : Nasopharyngeal aspirates (NPA) were collected from 863 hospitalized children with ALRI on the first day of admission at Soonchunhyang University Cheonan Hospital and analyzed by multiplex RT-PCR from December 2005 to November 2006.
Results
: Viral agents were detected from 474 subjects (54.9%). The identified viral pathogens were hRV 9.2%, hMPV 6.8 %, HCoV-229E/NL63 1.4%, and HCoV-OC43 2.1%. Coinfections with ≥2 viruses were observed in 108 patients (22.8%). The major period of viral ALRI was the first year of life. Clinical diagnoses of viral ALRI were pneumonia (59.5%), bronchiolitis (24.7%), tracheobronchitis (11.4%), and croup (4%). The most common causes of bronchiolitis was respiratory syncytial virus B (RSV B), whereas hMPV, hRV, HCoV-229E/NL63, and HCoV-OC43 were commonly found in patients with pneumonia. The number of hMPV infections peaked between March and May 2006. HCoV-OC43 was prevalent from November to February 2006, whereas HCoV-229E and hRV were detected throughout the year.
Conclusion
: Although the study was confined to one year, hMPV was not detected during winter and peaked between March and April, which was not consistent with previous studies. This present study indicates that HCoV is a less common respiratory pathogen in cases of ALRI in Korean children. |
| Key Words:
Respiratory virus, Respiratory infectionsm, RT-PCR, Children |
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