Korean Journal of Pediatrics 2008;51(8):886-891.
Published online August 15, 2008.
A case of mixed connective tissue disease presenting initially with Raynaud`s phenomenon
Soo Young Kim, Young Seok Choi, Young Ok Kim, Young Jong Woo
Department of Pediatrics, School of Medicine, Chonnam National University, Gwangju, Korea
레이노드 증후군으로 초기 발현된 복합 교원성 질환 1예
김수영, 최영석, 김영옥, 우영종
전남대학교 의과대학 소아과학교실
Mixed connective tissue disease (MCTD) is characterized by diverse symptoms including rheumatoid arthritis, scleroderma, systemic lupus erythematosus, and dermatomyositis, associated with high titers of antibodies to extractable nuclear antigen (ENA), especially anti-ribonucleoprotein (anti-RNP) antibody. Since the first report of 25 cases with MCTD in adults, there have been only a few cases of MCTD reported in children. Here, we report a rare childhood case of MCTD in a 7-year-old girl presenting initially with Raynaud`s phenomenon, swollen hands, and ulceration of the right index finger tip followed by alopecia and arthritis during follow-up.
Key Words: Mixed connective tissue disease, Raynaud`s phenomenon, Antibody to ribonucleoprotein

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