| Polymorphisms of interleukin-1β promoter in simple febrile seizures |
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Jang Won Yoon, Eun Jung Choen, Young Hyuk Lee |
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Department of Pediatrics, College of Medicine, Konyang University, Taejeon, Korea |
| 단순 열성 경련에서 interleukin-1β promoter 유전자의 다형성 |
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윤장원, 천은정, 이영혁 |
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건양대학교 의과대학 소아과학교실 |
Correspondence:
Eun Jung Choen, Email: koojook@medimail.co.kr
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| Abstract |
Purpose
: Febrile seizure (FS) is the most common type of seizure. The role of genetic factors in FSs has long been recognized. A positive family history can be elicited in 25-40% of patients with FSs; nonetheless, the genes responsible for FSs in the majority of the population remain unknown. Interleukin-1β (IL-1β) is a pro-inflammatory cytokine that acts as an endogenous pyrogen. Thus, IL-1β could be involved in the pathophysiology of FSs.
Methods
: To determine whether or not single nucleotide polymorphisms of the IL-1β gene are associated with susceptibility to simple FSs, IL-1β promoter -31 and -511 genotyping was performed by means of polymerase chain reaction-restriction fragment (PCR-RF) length polymorphism in 40 FS patients (20 sporadic and 20 familial FS patients) and 33 controls.
Results
: There were no significant differences in the frequencies of -31 C/T and -511 C/T in the IL-1β promoter gene, between simple FS patients and controls.
Conclusion
: The frequency of CT/CT increased relatively in familial FS patients. A study examining a larger number of FS patients is needed. |
| Key Words:
Simple febrile seizures, Interleukin-1β |
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