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The use of fluoroquinolone in children

Korean Journal of Pediatrics 2008;51(10):1042-1046.
Published online October 15, 2008.
The use of fluoroquinolone in children
Jae Kyun Hur
Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea
소아에서 fluoroquinolone 사용
가톨릭대학교 의과대학 소아과학교실
Jae Kyun Hur, Email: jkhur@catholic.ac.kr
The fluoroquinolones are an important group of antibiotics widely used in the treatment of various infectious diseases in adults, as a result of an excellent spectrum of activity, good tissue penetration and convenient ways of administration. In recent decades, there has been extensive development, clinical investigation, licensure and use of fluoroquinolone antibiotics. However, the use of fluoroquinolones in children has been limited because of their potential to induce arthropathy in juvenile animals. Despite class label warnings against use in children, prescriptions for quinolone antibiotics to treat infections in children have become increasingly prevalent. The main use of fluoroquinolones in pediatrics should be, understandably, in serious life-threatening infections for which other antibiotics therapies are not effective or available. While most of the published studies failed to detect an increased rate of articular adverse effects in children treated with fluoroquinolones, an increase in the use of these compounds, particularly in community-acquired lower respiratory infections, could accelerate the emergence of multidrug-resistant (including fluoroquinolone) pneumococcal strains. This review will discus the main issues related to the use of fluoroquinolones in children, the major problems of resistance developing among these compounds, with special emphasis on the potential side effects and skilled use of these alternative potent drugs in pediatric infection.
Key Words: Fluoroquinolone, Children

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