| Comparison of the seroconversion rate after primary hepatitis B vaccination and after revaccination of non-responders in full-term infants according to
mother's HBsAg seropositivity |
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Jang Hee Kang1, Jae Won Moon2, Seung Hyun Kong1, Kwang Su Hwang1, Ji Sun Mok1, Hyeon Jung Lee1 |
1Department of Pediatrics, Good Moonhwa Hospital, Busan, Korea
2Department of Pediatrics, Wallace Memorial Baptist Hospital, Busan, Korea |
| 산모의 HBsAg 보유 여부에 따른 만삭아의 B형간염 기본접종 및 무반응자에서 재접종 후 항체 양전율에 대한 연구 |
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강장희1, 문재원2, 공승현1, 황광수1, 목지선1, 이현정1 |
1좋은문화병원 소아청소년과
2왈레스기념 침례병원 소아청소년과 |
Correspondence:
Hyeon Jung Lee, Email: Leesoa07@yahoo.co.kr
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| Abstract |
Purpose
: This study aimed to identify the true extent of non-responsiveness in full-term infants born from HBsAg-negative or HBsAg-positive mothers and vaccinated against hepatitis B virus (HBV) at 0, 1, and 6 months of age and to evaluate the effect of revaccination among non-responders.
Methods
: The study included 716 full-term infants born in 2004-2007. Of 716, 662 infants (A group) were born to HBsAg- negative mothers and 54 infants (B group: 50, except HBsAg-positive infants) were born to HBsAg-positive mothers. All infants were administered DNA recombinant vaccines at 0, 1, and 6 months of age. B group infants received hepatitis B immunoglobulin at birth. Anti-HBs titers were tested at 7-12 and 9-15 months in A and B groups, respectively. Three revaccination doses were administered to non-responders whose anti-HBs titers were under 10 mIU/ml; revaccinated infants were retested at 1-3 months after last vaccination. The association between HBeAg seropositivity of mother and the failure of HBV immunoprophylaxis was evaluated.
Results
: The seroconversion rates after primary hepatitis B vaccination were higher in A group (94.1%) than in B group (78%, P<0.001). The seroconversion rates were high in revaccinated infants (A group non-responders: 96.9%, B group non- responders: 87.5%). The failure of HBV immunoprophylaxis was significantly associated with maternal HBeAg seropositivity (P<0.001).
Conclusion
: The seroconversion rates after primary hepatitis B vaccination were low in B group infants. Revaccination of non-responders in B group was very effective. Therefore, anti-HBs testing and revaccination of B group is very important. Revaccination of non-responders in A group was also very effective. Thus, testing the immune status of infants born to HBsAg-negative mothers even after primary hepatitis B vaccination should be considered. However, to realize this, further studies on the cost-effectiveness of anti-HBs testing in healthy full-term infants are necessary. |
| Key Words:
Hepatitis B revaccination, Anti-HBs, Non-responders |
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