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The significance of corpus callosal size in the estimation of neurologically abnormal infants

Korean Journal of Pediatrics 2008;51(11):1205-1210.
Published online November 15, 2008.
The significance of corpus callosal size in the estimation of neurologically abnormal infants
Seung Taek Yu, Chang Woo Lee
Department of Pediatrics, Wonkwang University College of Medicine, Iksan, Korea
신경학적인 결함이 있었던 영아의 예후 판단에서 뇌량 크기의 중요성
유승택, 이창우
원광대학교 의과대학 소아과학교실
Correspondence: 
Chang Woo Lee, Email: chan33@wonkwang.ac.kr
Abstract
Purpose
: The development of the corpus callosum occupies the entire period of cerebral formation. The myelination pattern on magnetic resonance imaging (MRI) is very useful to evaluate neurologic development and to predict neurologic outcome in high risk infants. The thickness of the corpus callosum is believed to depend on the myelination process. It is possible to calculate the length and thickness of the corpus callosum on MRI. Thus, we can quantitatively evaluate the development of the corpus callosum. We investigated the clinical significance of measuring various portions of the corpus callosum in neonate with neurologic disorders such as hypoxic brain damage and seizure disorder.
Methods
: Forty-two neonates were evaluated by brain MRI. We measured the size of the genu, body, transitional zone, splenium, and length of the corpus callosum. Each measurement was divided by the total length of the corpus callosum to obtain its corrected size. The ratio of corpus callosal length and the anteroposterior diameter of the brain was also measured.
Results
: There was no statistical significance in the sample size of each part of the corpus callosum. However, the corrected size or the ratio of body of the corpus callosum correlated with periventricular leukomalacia and hypoxic ischemic encephalopathy.
Conclusion
: The abnormal size of the corpus callosum showed a good correlation with periventricular leukomalacia and hypoxic ischemic encephalopathy in neonates. We can predict clinical neurological problems by estimation of the corpus callosum in the neonatal period.
Key Words: Corpus callosum, Hypoxia-ischemia, Brain, Leukomalacia, Periventricular


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