Korean Journal of Pediatrics 2009;52(1):36-43.
Published online January 15, 2009.
Angiotensinogen gene M235T polymorphism as a predictor of cardiovascular risk in hypertensive adolescents
Joo Hyun Gil, Jung Ah Lee, Eun Young Park, Young Mi Hong
Department of Pediatrics, School of Medicine, Ewha Womans University, Seoul, Korea
고혈압 청소년의 심혈관계 위험요소로서 Angiotensinogen M235T 유전자 다형
길주현, 이정아, 박은영, 홍영미
이화여자대학교 의학전문대학원 소아과학교실
Correspondence: 
Young Mi Hong, Email: hongym@chollian.net
Abstract
Purpose
: The renin-angiotensin system (RAS) has been demonstrated to play a major role in regulating blood pressure. Therefore, components of the RAS are likely candidate genes that may predispose an individual to essential hypertension and cardiovascular complications. Among them, the M235T polymorphism of the angiotensinogen gene has been speculated to be associated with elevated circulating angiotensinogen concentrations and essential hypertension. This study aimed to analyze the angiotensinogen M235T polymorphism in hypertensive adolescents and investigate its relationship with cardiovascular risks.
Methods
: Forty Korean hypertensive adolescents (aged 16-17, systolic BP ≥140 mmHg and/or diastolic BP ≥90 mmHg) and fifty seven normal adolescents were included. Obesity index (OI), body mass index (BMI) were calculated. BP was measured by oscillometric methods in resting state. Polymerase chain reaction (PCR) technique was performed on DNA from the hypertensives subjects to analyze the M235T polymorphism. Serum homocysteine, insulin, renin, aldosterone and angiotensin converting enzyme (ACE) were tested according to each genotype. The carotid intima-media thickness (IMT) and carotid artery diameter, Pulse wave velocity (PWV) and ankle-brachial index (ABI) were measured according to each genotype.
Results
: Genotype frequencies of T/T, M/T and M/M were 62.5%, 35.0%, 2.5%, respectively in hypertensive adolescents. The results were not significantly different compared to control group. Serum insulin, renin levels, BMI and OI were significantly higher in thoses with the M/M genotype as compared to those with the T/T of M/T genotype.
Conclusion
: This study showed that the M235T polymorphism was not associated with essential hypertension or any cardiovascular risks. Further clinical research is required to ascertain the relationship between this polymorphism and cardiovascular complications in Korean hypertensive adolescents.
Key Words: Hypertension, Adolescents, Angiotensinogen, Genes, Polymorphism


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