Korean Journal of Pediatrics 2009;52(1):56-60.
Published online January 15, 2009.
Rotavirus-associated neonatal necrotizing enterocolitis
Hyun Joo Seo, Yu Jin Jung, Soo Kyung Park, Seo Hui Choi, Ji Hyuk Lee, Myo Jing Kim, Yun Sil Chang, Won Soon Park
Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
로타바이러스 감염이 관련된 신생아 괴사성 장염
서현주, 정유진, 박수경, 최서희, 이지혁, 김묘징, 장윤실, 박원순
성균관대학교 의과대학 삼성서울병원 소아청소년과
Correspondence: 
Won Soon Park, Email: wonspark@skku.edu
Abstract
Purpose
: This study aimed to test whether rotavirus-associated necrotizing enterocolitis (RV+NEC) produced different clinical findings or outcomes from those of non-rotavirus necrotizing enterocolitis (RV-NEC).
Methods
: Eight patients from the RV+NEC group and 22 patients from the RV-NEC group diagnosed with modified Bell stage II or higher NEC were selected for this study. Fecal specimens from all infants were tested for rotavirus infection using a monoclonal antibody-based enzyme immunoassay (EIA). Clinical, radiographic, and clinical outcome data were analyzed retrospectively.
Results
: RV+NEC infants had a significantly higher birth weight and were born at a significantly higher gestational age (33.5¡¾3.3 weeks vs. 29.3¡¾4.4 weeks; P=0.01). There were no differences in the occurrence of thrombocytopenia, mural gas, and pneumoperitoneum between the 2 groups. However, portal vein gas was more common in the RV+NEC group (88% vs. 9%; P<0.01). Neither the incidence of Bell stage III (or higher) NEC nor surgical intervention differed between the two groups. The number of complications and mortality rates were also similar.
Conclusion
: Rotavirus-associated NEC occurs in infants with a higher birth weight and those born at a greater gestational age. However, the severity of the condition and the resulting outcomes did not differ from those for infants affected by non-rotavirus NEC.
Key Words: Rotavirus infections, Enterocolitis, Necrotizing, Newborn


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