Korean Journal of Pediatrics 2009;52(1):87-92.
Published online January 15, 2009.
The relationship between catechol-O-methyltransferase gene polymorphism and coronary artery abnormality in Kawasaki disease
Hyo Jin Lee1, Myung Sook Lee1, Ji Sook Kim1, Eun Ryoung Kim1, Sung Wook Kang2, Soo Kang Kim2, Joo Ho Chun2, Kyung Lim Yoon3, Mi Young Han4, Seong Ho Cha4
1Department of Pediatrics, Sung-Ae General Hospital, Seoul, Korea
2Department of Pediatrics, Kohwang Medical Research Institute, School of Medicine, Kyunghee University, Seoul, Korea
3Department of Pediatrics, East-West Neo-medical Center, Kyunghee University, Seoul, Korea
4Department of Pediatrics, College of Medicine, Kyunghee University, Seoul, Korea
가와사키병의 관상동맥 이상과 catechol-O-methyltransferase 유전자의 단일염기다형성
이효진1, 이명숙1, 김지숙1, 김은령1, 강성욱2, 김수강2, 정주호2, 윤경림3, 한미영4, 차성호4
1성애병원 소아청소년과
2경희대학교 고황의학연구소
3경희대학교 동서신의학병원 소아과청소년과
4경희대학교 의과대학 소아과학교실
Correspondence: 
Eun Ryoung Kim, Email: eunicu@hotmail.com
Abstract
Purpose
: Many gene polymorphisms are associated with coronary artery abnormalities in Kawasaki disease. Catechol-O- methyltransferase (COMT) plays an important role in the metabolism of catecholamines, catechol estrogen, and catechol drugs. Polymorphisms of the COMT gene are reported to be associated with myocardial infarction and coronary artery abnormalities. The aim of this study was to evaluate the relationship between COMT gene polymorphisms and coronary artery abnormalities in Kawasaki disease patients.
Methods
: One hundred and one Korean children with Kawasaki disease and 306 healthy Korean control subjects were enrolled in this study. The polymorphisms of the COMT gene were analyzed by direct sequencing.
Results
: There were no differences in the genotype and allelic frequency of the rs4680 and rs769224 polymorphic sites between Kawasaki disease and control subjects. Further, no significant difference was found in the rs4680 polymorphism between patients with coronary artery abnormalities and patients without coronary artery abnormalities (codominant P=0.32, dominant P=0.74, recessive P=0.13). However, the distribution of the rs769224 polymorphism was significantly different between patients with coronary artery abnormalities and patients without coronary artery abnormalities (codominant P= 0.0077, dominant P=0.0021, recessive P=0.16).
Conclusion
: Our results indicate that the polymorphisms of the rs769224 gene might be related to the development of coronary artery abnormalities in Kawasaki disease.
Key Words: Mucocutaneous lymph node syndrome, Kawasaki disease, Coronary artery disease, Genetic polymorphism, Catechol-O-Methyltransferase


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