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Multicenter clinical study on birth weight and associated anomalies of single umbilical artery

Korean Journal of Pediatrics 2009;52(6):655-660.
Published online June 15, 2009.
Multicenter clinical study on birth weight and associated anomalies of single umbilical artery
Su-Nam Bae1, Jae-Woo Lim1, Kyong-Og Ko1, Hyun-Seung Jin2, Min-Hee Kim3, Bo-Young Lee4, Chun-Soo Kim4, Eun-Ryoung Kim5, Sang-Kee Park6, Jung-Joo Lee7
1Department of Pediatrics, College of Medicine, Konyang University
2Department of Pediatrics, Gangneung Asan Medical Hospital
3Department of Pediatrics, College of Medicine, Konkuk University Hospital
4Department of Pediatrics, College of Medicine, Keimyung University Hospital
5Department of Pediatrics, College of Medicine, Sung-Ae General Hospital
6Department of Pediatrics, College of Medicine, Chosun University Hospital
7Department of Pediatrics, College of Medicine, Chung Ang University, Seoul, Korea
단일 배꼽 동맥 환아의 출생체중과 동반기형에 관한 다기관 연구
배수남1, 임재우1, 고경옥1, 진현승2, 김민희3, 이보영4, 김천수4, 김은령5, 박상기6, 이정주7
1건양대학교 의과대학 소아과학교실
2강릉아산병원 소아청소년과
3건국대학교 의과대학 소아과학교실
4계명대학교 의과대학 소아과학교실
5성애병원 소아청소년과
6조선대학교 의과대학 소아과학교실
7중앙대학교 의과대학 소아과학교실
Jae-Woo Lim, Email: limsoa@hanmail.net
: To compare birth weight between infants with a single umbilical artery (SUA) and normal infants, investigate the associated anomalies of infants with SUA and isolated SUA (no abnormality of external appearance on birth, except SUA), and determine the prognosis of infants with isolated SUA.
: Live-born infants with SUA (n=59) detected by physical examination from among 15,193 live births in seven university hospitals in Korea between January 1, 2004, to August 1, 2007, were reviewed retrospectively, with 236 normal infants serving as the control group.
: A statistical difference was observed between the groups in birth weight and in vitro fertilization. The incidence of infants with SUA was 0.37%. Congenital malformations were observed in 21 infants with cardiovascular (n=15, 25.4%), gastrointestinal (n=2, 3.4%), genitourinary (n=9, 15.3%), neuromusculoskeletal (n=6, 10.2%), central nervous system (n=1, 1.7%), chromosomal (n=1, 1.7%), and other (n=3, 5.1%) abnormalities. There were 49 (83.1%) infants with isolated SUA in this study population; among them, the associated congenital malformations were cardiovascular (n=6, 12.2%) and genitourinary (n=6, 12.2%) abnormalities. Two infants with cyanotic heart disease were operated and four infants with acyanotic heart disease showed improvements without any treatment. Six infants with genitourinary abnormalities on renal ultrasound had mild hydronephrosis without further consequences.
: The incidence of structural abnormalities in the cardiovascular and genitourinary systems is high and the genitourinary anomalies associated with isolated SUA have relatively good prognosis.
Key Words: Umbilical artery, Congenital malformation

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