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A case of newly developed pulmonary lesion during the antitubercular agents in tuberculous pleurisy : A paradoxical response

Korean Journal of Pediatrics 2009;52(6):717-720.
Published online June 15, 2009.
A case of newly developed pulmonary lesion during the antitubercular agents in tuberculous pleurisy : A paradoxical response
Jee Min Park1, Youn Ho Shin2, Gyu Rak Chon3, Hyun Joon Shin4, Young Chil Choi5
1Department of Pediatrics, Ajou University School of Medicine, Suwon, Korea
2Department of Pediatrics, Pochon CHA University, College of Medicine, Seoul, Korea
3Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Konkuk University College of Medicine, Chungju, Chungbuk, Korea
4Department of Radiology, Konkuk University College of Medicine, Chungju, Chungbuk, Korea
5Department of Radiology, Konkuk University College of Medicine, Chungju, Chungbuk, Korea
결핵흉막염 치료중에 새로이 발생한 폐병변 1예 :역설적 반응
박지민1, 신윤호2, 전규락3, 신현준4, 최영칠5
1아주대학교 의과대학 소아과학교실
2포천중문의과대학 소아과학교실
3건국대학교 충주병원 내과학교실
4건국대학교 충주병원 방사선과교실
5건국대학교 충주병원 방사선과교실
Correspondence: 
Jee Min Park, Email: cpr1@medigate.net
Abstract
Paradoxical response refers to the enlargement of old lesions or unexpected appearance of new lesions after initial improvement following treatment with antitubercular agents. Various types of paradoxical responses have been reported in the world, but they are rarely reported in Korean children. We report the case of a 17-year-old boy who was diagnosed with tuberculous pleurisy and was treated appropriately. Although the tuberculous pleurisy initially responded to medication with resolution of the pleural fluid, a new pulmonary lesion subsequently developed 3 weeks after the initiation of treatment that eventually cleared with continuation of the original drug regimen.
Key Words: Paradoxical response, Tuberculous pleurisy, Antitubercular agents


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