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Serum leptin, adiponectin and resistin levels in obese children and their correlations with insulin resistance

Korean Journal of Pediatrics 2009;52(7):766-771.
Published online July 15, 2009.
Serum leptin, adiponectin and resistin levels in obese children and their correlations with insulin resistance
Min Young Park, Sun A Ahn, Won Kyoung Cho, Kyoung Soon Cho, So Hyun Park, Seung Hoon Hahn, Min Ho Jung, Byung-Kyu Suh
Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea
비만 아동에서 leptin, adiponectin 및 resistin의 혈중농도와 인슐린 저항성과의 관계
박민영, 안선아, 조원경, 조경순, 박소현, 한승훈, 정민호, 서병규
가톨릭대학교 의과대학 소아과학교실
Correspondence: 
Byung-Kyu Suh, Email: suhbk@catholic.ac.kr
Abstract
Purpose
: The objective of this study was to compare the levels of adipocytokines in obesity group with those in control group and examine their correlation with insulin resistance.
Methods
: We enrolled 36 obese children (male:female [M:F]=17:19; age, 9.3±1.9 yrs) with ≥95th percentile body mass indexes (BMIs) (obesity group) and 35 healthy children (M:F=16:19; age, 9.1±2.1 yrs) with 25th-75th percentile BMIs (control group). We measured the serum leptin, adiponectin, and resistin levels and insulin resistance in both the groups.
Results
: The weights, heights, BMIs, fasting sugar levels, insulin levels, and homeostasis model assessment for insulin resistance (HOMA-IR) values were higher in the obesity group than in the control group. As compared to the control group, the obesity group showed significantly higher leptin levels and lower adiponectin levels; no significant difference was observed in the resistin levels. The leptin/adiponectin (L/A) ratio was higher in the obesity group than in the control group. In the obesity group, HOMA-IR showed significant positive correlations with weight, height, BMI, and leptin level. However, it was not correlated with age and adiponectin and resistin levels. In the obesity group, leptin level showed significant positive correlations with age, weight, height, and BMI, while adiponectin and resistin levels showed no such correlations with the other variables.
Conclusion
: We suggest that adiponectin plays an important protective role against weight gain in obese children. Further, L/A ratio can be used as a parameter for predicting the prognosis of obese children.
Key Words: Leptin, Adiponectin, Resistin, Insulin Resistance, Children


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