| Novel swine-origin H1N1 influenza |
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Jina Lee, Hoan Jong Lee |
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Department of Pediatrics, Seoul National University Children`s Hospital, Seoul, Korea |
| 신종 H1N1 인플루엔자 |
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이진아, 이환종 |
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서울대학교 의과대학 소아과학교실 |
Correspondence:
Hoan Jong Lee, Email: hoanlee@snu.ac.kr
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| Abstract |
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Since its identification in April 2009, a swine-origin H1N1 influenza A virus (S-OIV) which is a reassortment of gene segments
from both North American triple-reassortant and Eurasian swine influenza has been widely spread among humans in unexpected
rapidity. To date, each gene segment of the 2009 influenza A (H1N1) outbreak viruses have shown high (99.9%) neucleotide
sequence identity. As of July 6, 94,512 people have been infected in 122 countries, of whom 429 have died with an overall
case-fatality rate of <0.5%. Most confirmed cases of S-OIV infection have been characterized by self-limited, uncomplicated
febrile respiratory illness and 38% of cases have also included vomiting or diarrhea. Standard plus droplet precautions should
be adhered to at all times. Tests on S-OIV have indicated that current new H1N1 viruses are sensitive to neuraminidase inhibitors
(oseltamivir). However, current less virulent S-OIV may evolve into a pathogenic strain or acquire antiviral resistance, potentially
with more severe clinical consequences. Efforts to control these outbreaks would be based on our understanding of novel
S-OIV and previous influenza pandemics. |
| Key Words:
Novel swine-origin H1N1 influenza, S-OIV, Pandemic, Vaccine |
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