| The effects of neonatal ventilator care or maternal chorioamnionitis on the development of bronchopulmonary dysplasia |
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Ki Tae Yun, Whan Dong Lee, Sang Geel Lee |
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Department of Pediatrics, Fatima Hospital, Daegu, Korea |
| 산모의 융모양막염 및 인공호흡기 치료가 미숙아 만성 폐질환의 발생에 미치는 영향 |
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윤기태, 이동환, 이상길 |
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대구 파티마병원 소아청소년과 |
Correspondence:
Sang Geel Lee, Email: sgleeped@korea.com
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| Abstract |
Purpose
Advances in neonatal intensive care have improved the survival rate of low-birth-weight infants, but mild bronchopulmonary
dysplasia (BPD) with the accompanying need for prolonged oxygen supplement remains problematic. Maternal chorioamnionitis
and neonatal ventilator care affect the development of BPD. This study aimed to examine whether maternal chorioamnionitis
or neonatal ventilator care affect the development of BPD dependently or independently.
Methods
We performed a retrospective study of 158 newborn infants below 36 weeks of gestational age and 1,500 gm
birth weight admitted to the neonatal intensive care unit of Daegu Fatima Hospital between January 2000 and December 2006.
We analyzed the incidence of BPD according to maternal chorioamnionitis and neonatal ventilator care.
Result:Histologic chorioamnionitis was observed in 50 of 158 infants (31.6%). There were no significant differences in the
development of BPD (P=0.735) between the chorioamnionitis (+) and chorioamnionitis (-) groups. In the multiple regression
analysis, ventilator care (OR=7.409, 95% CI=2.532-21.681) and neonatal sepsis (OR=4.897, 95% CI=1.227-19.539) affected the
development of BPD rather than maternal chorioamnionitis (OR=0.461, 95% CI=0.201-1.059).
Conclusion
Ventilator care or neonatal sepsis may play a role in the development of BPD rather than maternal chorioamnionitis. |
| Key Words:
Chorioamnionitis, Mechanical ventilators, Bronchopulmonary dysplasia |
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