| Comparison and analysis of the effectiveness to high dose of aspirin and
ibuprofen in acute phase of Kawasaki disease |
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Seung-woon Keum, Yeon Kyun Oh, Jong Duck Kim, Seung-taek Yu |
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Departments of Pediatrics, Wonkwang University College of Medicine, Iksan, Korea |
| 가와사끼병의 급성기 치료에서 고용량 아스피린과 고용량 이부프로펜 사용 효과 비교 분석 |
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금승운, 오연균, 김종덕, 유승택 |
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원광대학교 의과대학 소아과학교실 |
Correspondence:
Seung-taek Yu, Email: yudoc@wonkwang.ac.kr
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| Abstract |
Purpose
We evaluated the effectiveness of treatment and cardiac complications of replacing a high dose of aspirin with a
high dose of ibuprofen for children in acute phase of Kawasaki disease. We also analyzed the possibility of replacing a high
dose of aspirin with a high dose of ibuprofen to prevent complications such as Reye s syndrome caused by aspirin.
Methods
One hundred eight children with Kawasaki disease were admitted in the pediatrics department from January 1,
2004 to December 31, 2008. Echocardiography and laboratory tests were performed during diagnosis, and the children were
followed-up at 6-8 weeks after the diagnosis. We retrospectively analyzed their characteristics and clinical results.
Results
The children were assigned to receive either a high dose of aspirin with intravenous immunoglobulin (IVIG) (aspirin
group) or a high dose of ibuprofen with IVIG (ibuprofen group). A total of 55 and 53 children were included in the aspirin and
ibuprofen groups, respectively. The mean defervescence period was 6.5¡¾2.1 days in the aspirin group, and 6.9¡¾1.9 days in
the ibuprofen group (P=0.309). The number of failed treatments, during and after treatment, was 8 in the aspirin group and
10 in the ibuprofen group (P=0.547). There were 11 initial cardiac complications in the aspirin group, and 14 in the ibuprofen
group, but children who showed improvement at follow-up was 7 and 13 in the aspirin and ibuprofen groups, respectively (P=
0.133). Laboratory findings were also improved in both groups.
Conclusion
We can be considered whether we will replace high dose of aspirin by high dose of ibuprofen in acute phase
of Kawasaki disease. Therefore, we can prevent the severe complications of aspirin use, such as Reye s syndrome. |
| Key Words:
Mucocutaneous Lymph Node Syndrome, Aspirin, Ibuprofen |
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