| Metabolic syndrome in the overweight and obese adolescents and the impact
of obesity on the cardiovascular system |
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Yong Mi Hong1, Young Young Song2, Hae Soon Kim1, Hae Sook Park3, Jung Hae Min4, Jo Won Jung5, Nam Soo Park6, Chung Il Noh7 |
1Department of Pediatrics, Ewha Womans University, Korea
2Department of Pediatrics, College of Medicine, Inje University, Korea
3Department of Preventive Medicine, Ewha Womans University, Korea
4Department of Pediatric, Hong Ik Hospital, Seoul, Korea
5Department of Pediatrics, College of Medicine, Ajou University, Suwon, Korea
6Department of Pediatrics, College of Medicine, Han Yang University, Seoul, Korea
7Department of Pediatrics, College of Medicine, Seoul National University, Seoul, Korea |
| 과체중과 비만 청소년에서 대사증후군과 비만이 심혈관에 미치는 영향 |
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홍영미1, 송영환2, 김혜순1, 박혜숙3, 민정혜4, 정조원5, 김남수6, 노정일7 |
1이화여자대학교 의과전문대학원 소아과학교실
2인제대학교 의과대학 소아과학교실
3이화여자대학교 의과전문대학원 예방의학교실
4홍익병원 소아과
5아주대학교 의과대학 소아과학교실
6한양대학교 의과대학 소아과학교실
7서울대학교 의과대학 소아과학교실 |
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| Abstract |
Purpose
: Metabolic syndrome (MS), characterized by obesity and insulin resistance, elicits risk factors such as hyperlipidemia, hypertension, and glucose intolerance with additive effects on atherosclerosis, leading to cardiovascular diseases. The purposes of this study were to evaluate the prevalence of MS among overweight and obese adolescents and to investigate the impact of obesity on the cardiovascular system.
Methods
: In all, 684 adolescents were included in the study. Blood pressure, body mass index (BMI), fasting blood glucose, total cholesterol, triglyceride, low-density-lipoprotein (LDL)-cholesterol, high-density-lipoprotein (HDL)-cholesterol, aspartate aminotransferase (AST), alanine aminotransferase (ALT), and high-sensitive C-reactive protein (hs-CRP) were measured in the patients with a BMI of >85 percentile. Brachial-ankle pulse wave velocity (BaPWV) and ankle brachial index were measured using Vascular Profiler (VP)-1000.
Results
: MS was confirmed in 19.5% of the overweight and obese adolescents and 50.8% of the obese adolescents. The systolic and diastolic blood pressure, height, weight, fat mass, %fat, BMI, obesity index, and waist circumference were higher in the overweight and obese adolescents with MS. Moreover, the triglyceride, AST, ALT, and hs-CRP levels were higher, whereas HDL-cholesterol level was significantly lower in this group. The overweight and obese adolescents with MS showed shorter diastolic and systolic times, higher heart rate and BaPWV, and longer E-wave deceleration time by echocardiography.
Conclusion
: Overweight and obese adolescents showed characteristic MS features such as hypertension and hyperlipidemia. Thus, obese adolescents predisposed to MS should be provided early treatment for obesity. |
| Key Words:
Metabolic syndrome, Obesity, Heart diseases, Adolescent |
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