Korean Journal of Pediatrics 2009;52(10):1127-1135.
Published online October 15, 2009.
Magnetic resonance imagining findings of the white matter abnormalities in the brain of very-low-birth-weight infants
Jae Hyuk Choi, Young Pyo Chang
Department of Pediatrics, College of Medicine, Dankook University, Cheonan, Korea
극소 저체중 출생아에서 뇌백질 병변의 MRI 소견
최재혁, 장영표
단국대학교 의과대학 소아과학교실
: To observe the abnormal white matter findings on the magnetic resonance imaging (MRI) scans of very-low- birth-weight (VLBW) infant brains at term-equivalent age and to determine the clinical risk factors for the development of periventricular leukomalacia (PVL).
: In all, MRI was performed in 98 VLBW infants and the white matter abnormalities were observed. Clinical risk factors for cystic and noncystic PVL were determined.
: MRI scans of 74 infants (75.5%) showed diffuse excessive high signal intensity (DEHSI) in the periventricular white matter, 17 (17.3%) lateral ventricle dilation, 5 (5.1%) and 11 (11.2%) focal punctate lesions and cystic changes in the periventricular white matter, respectively, 9 (9.1%), germinal layer hemorrhage (GLH) or subependymal cysts 3 (3.1%) intraventricular hemorrhage (>grade 2) 2 (2.0%) posthemorrhagic hydrocephalus and 2 (2.0%) periventricular hemorrhagic infarct. Gestational age (GA), 1-minute Apgar score, Clinical Risk Index for Babies-II (CRIB-II) score, and inotrope use, and GA, CRIB-II score, postnatal steroid administration, inotrope use, and abnormal white blood cell (WBC) count at admission were related to cystic PVL and noncystic PVL development, respectively (P<0.05). However, in logistic regression analysis, CRIB-II (odds ratio, 1.63, 295% confidence interval, 1.15–2.30 P=0.006) for cystic PVL, and GA (odds ratio 0.90, 95% confidence interval, 0.82–0.99 P=0.036) for noncystic PVL were only significant independently.
: White matter abnormalities could be observed on MRI scans of the VLBW infant brains at term-equivalent age, and CRIB-II and GA were only independently significant for cystic and noncystic PVL development, respectively.
Key Words: Leukomalacia, Periventricular, Magnetic resonance imaging, Infant, Very low birth weight

METRICS Graph View
  • 2,028 View
  • 534 Download

Close layer
prev next