Korean Journal of Pediatrics 2009;52(10):1140-1146.
Published online October 15, 2009.
Association of ionized magnesium, total magnesium, gestational age, and intraventricular hemorrhage in preterm babies
Tae-Yeon Kim, Hyun-Hee Lee, Tae-Jung Sung
Department of Pediatrics, College of Medicine, Hallym University, Seoul, Korea
미숙아에서 이온화 마그네슘, 총 마그네슘과 재태 연령과의 관계 및 뇌실 내 출혈과의 관계
김태연, 이현희, 성태정
한림대학교 의과대학 소아과학교실
Correspondence: 
Tae-Jung Sung, Email: neosung@hallym.or.kr
Abstract
Purpose
: The pathophysiology of magnesium, the second highest common compound in humans, is still unclear, especially in preterm babies. We accessed the association between total magnesium (tMg), ionized Mg (iMg), and gestational age (GA) and that between serum magnesium (sMg) and intraventricular hemorrhage (IVH) in preterm babies.
Methods
: In all, 119 inborn preterm infants admitted between July 2006 and February 2008 were divided into the IVH group (19) and the control group (100) and were prospectively analyzed. TMg, iMg, pH, total calcium (tCa), and ionized Ca (iCa) levels were determined immediately after delivery or within 3 hours after birth, and their correlation with GA were investigated.
Results
: TMg was not correlated with GA, tCa, iCa, and pH. IMg was correlated with tMg (r=0.288, P=0.002) and iCa (r=0.212, P=0.021); however, it was not correlated with GA and pH. Mean GA and birth weight were significantly lower (P=0.002) and smaller (P=0.030) in the IVH group. Mean sMg was higher in the IVH group (2.5¡¾0.9 mg/dL) than in the control group (2.1¡¾0.6 mg/dL) (P=0.021). SMg was a risk factor even after logistic regression analysis (OR, 2.798; 95% C.I., 1.265-6.192; P=0.011).
Conclusion
: In less than 37-week-old preterm babies, tMg and iMg were similar, regardless of GA. High sMg may be a risk factor for IVH in premature babies, regardless of their exposure to antenatal magnesium.
Key Words: Magnesium, Ionized magnesium, Gestational age, Intraventricular hemorrhage


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