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Molecular identification and clinical features of enteroviral infection in children of central Korea: An overview of enteroviral epidemiology between spring 2005 and autumn 2006

Korean Journal of Pediatrics 2009;52(11):1234-1240.
Published online November 15, 2009.
Molecular identification and clinical features of enteroviral infection in children of central Korea: An overview of enteroviral epidemiology between spring 2005 and autumn 2006
Eui Jung Roh2, Yong Man Jin1, Eun Hee Chung1, Young Pyo Chang1, Woo Sung Park1, Kwisung Park3, Young Mee Jee4
1Department of Pediatrics, College of Medicine, Dankook University, Cheonan, Chungcheongnam-Do, Korea
2Department of Pediatrics, College of Medicine, Konyang University Daejeon, Korea
3Health and Environment Research Institute, Daejeon, Korea
4Division of Enteric and Hepatitis Viruses, Department of Virology, National Institute of Health, Korea Center for Disease Control and Prevention, Seoul, Korea
2005년 봄부터 2006년 가을까지 국내 중부지역의 enterovirus 감염의 분자유전학 조사와 임상양상
노의정2, 진용만1, 정은희1, 장영표1, 박우성1, 박귀성3, 지영미4
1단국대학교 의과대학 소아과학교실
2건양대학교 의과대학 소아과학교실
3충청남도 보건환경연구회
4질병관리본부 간염, 장바이러스과
Correspondence: 
Eun Hee Chung, Email: ehchung@dankook.ac.kr
Abstract
Purpose
: Enteroviruses (EVs) are commonly known to cause infection, especially in infants and children. This report presents an overview of enterovirus epidemiology in central Korea.
Methods
: From the spring of 2005 to the autumn of 2006, we collected the cerebrospinal fluid (CSF) and stool samples from the pediatric patients with a febrile illness or suspected meningitis who were admitted to hospitals in central Korea. In order to test for EVs, cell lines were derived from pretreated susceptible specimen, and the cytopathic effects were observed. Seminested real time-polymerase chain reaction (RT-PCR) and direct sequencing were performed for genotypic and phylogenetic analyses.
Results
: Of the 305 patients examined, 51 (16.7%) tested positive for EV. Of these 51 patients, 44 showed the following serotypes: Echovirus (ECV) 18 (18 cases, 35.2%), Coxsackievirus B (CVB) 5 (13 cases, 25.4%), ECV25 (5 cases, 9.8%), ECV9 (4 cases, 7.8%), ECV5 (3 cases, 5.8%), and EV74 (1 case, 1.9%). In 2005, between June and August, ECV18 and CVB5 were mostly responsible for the enteroviral infections among the patients in central Korea. In 2006, between July and August, ECV25 was mostly the cause of enteroviral infection.
Conclusion
: There is a need for continuous surveillance of enteroviral infection and its clinical manifestations, particularly for EV74, which was first identified in Korea.
Key Words: Children, Enterovirus, RT-PCR, Enterovirus 74


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