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Changes in the expression of cytokines and apoptosis-related genes in children with infectious mononucleosis

Korean Journal of Pediatrics 2009;52(12):1348-1357.
Published online December 15, 2009.
Changes in the expression of cytokines and apoptosis-related genes in children with infectious mononucleosis
Dae Sun Jo1, Ji Hye Han1, Sun Young Kim2, Min Sun Kim1, Ho Keun Yi3, Dae-Yeol Lee1, Pyoung Han Hwang1
1Department of Pediatrics, Chonbuk National University, Jeononju, Korea
2Department of Pediatrics, Medical School, Research Institute of Clinical Medicine, Chonbuk National University, Jeononju, Korea
3Department of Biochemistry, School of Dentistry, Chonbuk National University, Jeononju, Korea
소아의 전염성 단핵구증에서 사이토카인과 세포자멸사 연관 유전자의 발현의 변화
조대선1, 한지혜1, 김선영2, 김민선1, 이호근3, 이대열1, 황평한1
1전북대학교 의과대학 소아과학교실
2전북대학교 의과대학 임상의학연구소
3전북대학교 치과대학 생화학교실
Correspondence: 
Pyoung Han Hwang, Email: hwaph@chonbuk.ac.kr
Abstract
Purpose
: The aims of this study were to identify the clinical characteristics and determine the changes in the expression of cytokines and apoptosis-related genes in children with infectious mononucleosis.
Methods
: Serological examinations of 15 pediatric patients diagnosed with infectious mononucleosis were performed prospectively. Peripheral blood from the patients was used to compare the composition of T cell subsets, cytokines, Epstein–Barr virus (EBV) DNA, and the expression of apoptosis-related genes with those in 10 healthy children.
Results
: Mean age of the patient group was 5.7±3.4 (range, 3–9) years, and the male-to-female ratio was 1.5:1. Fever, sore throat, pharyngitis/tonsillitis, and cervical lymph node enlargement were the most common symptoms and signs. The proportions of CD3+ T cells, CD8+ suppressor cells, and CD56+ natural killer (NK) cells were higher in the patient group than in the control group (P<0.01). The IL-2, IL-6, and interferon (IFN)-γ levels were higher in the early symptomatic period (P<0.01). Mean amount of EBV DNA in the patients was 102.38 copies/μg, and the amount was the highest at the beginning of the symptomatic period and normalized during the convalescent phase. Bcl-2 expression increased during the initial phase, while Bax expression increased during the convalescent phase. Further, FasL expression increased 1 week after symptom presentation and decreased during the convalescent phase. There was no significant change in Fas expression.
Conclusion
: We analyzed the clinical characteristics and changes in the expression ofcytokines and apoptosis-related genes in the patients with infectious mononucleosis.
Key Words: Infectious Mononucleosis, Cytokines, Apoptosis, Children, Gene


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