Korean Journal of Pediatrics 2010;53(1):48-55.
Published online January 15, 2010.
Regional outbreak of staphylococcal scalded skin syndrome in healthy children
Hyun Jeong Do, Eun Sil Park, Jae Young Lim, Chan Hoo Park, Hyang Ok Woo, Hee Shang Youn, Ji Hyun Seo
Department of Pediatrics, Gyeongsang National University College of Medicine, Jinju, Korea
건강한 소아에서 포도알균화상피부증후군의 지역적 유행
도현정, 박은식, 임재영, 박찬후, 우향옥, 윤희상, 서지현
경상대학교 의과대학 소아과학교실
Correspondence: 
Ji Hyun Seo, Tel: +82.55-750-8731, Fax: +82.55-752-9339, Email: seozee@gnu.ac.kr
Abstract
Purpose
: Staphylococcal scalded skin syndrome (SSSS) is a relatively uncommon superficial blistering skin disease that is due to Staphylococcus aureus. We had experienced a regional outbreak of SSSS over 3 years in healthy children.
Methods
: We retrospectively reviewed the medical records of those patients diagnosed as SSSS. Most of neonatal cases were nosocomial infections and excluded from the analysis. The clinical features, laboratory findings, the isolation and antibiotic resistance of S. aureus, the antibiotic management and other supportive treatments were analyzed.
Results
: Fifty-five patients with SSSS were admitted to our hospital from October 2001 to September 2004. The median age of patients was 3.0 years. Of the 55 patients, 9 were the generalized type, 13 were the intermediate type and 33 were the scarletiniform rash. All the patients were living in neighborhood of the Jinju area. S. aureus were isolated from 9 of the patients and all of the isolated S. aureus were methicillin resistant. All the patients except two were treated with intravenous flocloxacillin or nafcillin and/or cefotaxime. All the patients recovered during the follow-up period of 2 to 3 weeks.
Conclusion
: We experienced a regional outbreak of SSSS in previous healthy children. Further study for finding the carriers of S. aureus caused SSSS and preventing the spread of this disease is needed. Additionally, guidelines for treating SSSS due to methicillin resistant S. aureus should be established.
Key Words: Staphylococcal Scaled Skin Syndrome, Outbreak, Methicillin Resistant Staphylococcus aureus


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