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Association between polymorphisms in Interleukin-17 receptor A gene and childhood IgA nephropathy

Korean Journal of Pediatrics 2010;53(2):215-221.
Published online February 15, 2010.
Association between polymorphisms in Interleukin-17 receptor A gene and childhood IgA nephropathy
Seung-Ah Baek1, Won-Ho Hahn1, Byoung-Soo Cho, Sung-Do Kim2
0Department of Pediatrics, School of Medicine, East West Kidney Diseases Research Institute, Kyung Hee University, Seoul, Korea
1Department of Pediatrics, School of Medicine, Kyung Hee University, Seoul, Korea
2Department of Pediatrics, East West Kidney Diseases Research Institute, Kyung Hee University, Seoul, Korea
IgA 신병증 환자에서 Interleukin-17 수용체 A 유전자의 단일염기다형성 연관성 연구
백승아1, 한원호1, 조병수, 김성도2
0경희대학교 의과대학 소아과학교실, 경희대 동서신장병 연구소
1경희대학교 의과대학 소아과학교실
2경희대 동서신장병 연구소
Correspondence: 
Sung-Do Kim, Tel: +82.2-958-8295, Fax: +82.2-967-1382, Email: kimsungdo@empal.com
Abstract
Purpose
: Interleukin-17 (IL-17) is produced by activated CD4+T cells and exhibits pleiotropic biological activity on various cell types. IL-17 was reported to be involved in the immunoregulatory response in IgA nephropathy (IgAN). Our aim was to investigate the association between single-nucleotide polymorphisms (SNPs) in IL-17 receptor A (IL-17RA) gene and childhood IgAN.
Methods
: We analyzed the SNPs in the IL-17RA in 156 children with biopsy-proven IgAN and 245 healthy controls. We divided the IgAN patients into 2 groups and compared them with respect to proteinuria (≤4 and >4 mg/m2/h, ≤40 and >40 mg/m2/h, respectively) and the presence of pathological levels of biomarkers of diseases such as interstitial fibrosis, tubular atrophy, or global sclerosis.
Results
: No difference was observed between the SNP genotypes rs2895332, rs1468488, and rs4819553 between IgAN patients and control subjects. In addition, no significant difference was observed between allele frequency of SNPs rs2895 332, rs1468488, and rs4819553 between patients in the early and advanced stage of the disease. However, significant difference was observed between the genotype of SNP rs2895332 between patients with proteinuria (>4 mg/m2/h) and those without proteinuria (codominant model OR 0.36, 95% CI 0.19–0.66, P<0.001; dominant model OR 0.35, 95% CI 0.17–0.69 P=0.002; recessive model OR 0.12, 95% CI 0.01–1.06 P=0.025).
Conclusion
: Our results indicate that the SNP in IL-17RA (rs2895332) may be related to the development of proteinuria in IgAN patients.
Key Words: Glomerulonephritis, IGA, Receptor, Interleukin-17, Children, Polymorphism


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