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Association of HLA-G gene promoter haplotype with childhood IgA nephropathy in the Korean population

Korean Journal of Pediatrics 2010;53(4):548-553.
Published online April 15, 2010.
Association of HLA-G gene promoter haplotype with childhood IgA nephropathy in the Korean population
Hwan Hee Jung, Won Ho Hahn, Byoung Soo Cho, Sung Do Kim
Department of Pediatrics, Kyunghee University College of Medicine, Seoul, Korea
한국인에서의 소아 IgA 신병증과 HLA-G유전자의 promoter haplotype과의 관계
정환희, 한원호, 조병수, 김성도
경희대학교 의과대학 소아과학교실
Sung Do Kim, Email: kimsungdo@empal.com
: IgA nephropathy (IgAN) is the most commonly occurring form of chronic glomerulonephritis in pediatric cases.Human leukocyte antigen (HLA) genes have been implicated in various inflammatory and autoimmune diseases. The present study was conducted to investigate the association between 2 single nucleotide polymorphisms (SNPs) of the HLA-G gene and childhood IgAN.
: The authors analyzed and compared HLA-G gene SNPs (rs1736936 and rs2735022) in 174 patients with childhood IgAN and in 438 healthy controls. In addition, IgAN patients were dichotomized and compared with respect to proteinuria (< and >4 mg/m2/hour), the presence or absence of podocyte foot process effacement, and the presence of pathologically early and advanced disease markers such as interstitial fibrosis, tubular atrophy, or global sclerosis.
: No significant SNP frequency differences were observed for the HLA-G gene between IgAN patients and the control group. Moreover, no significantly associated SNP was observed with the presence of proteinuria, podocyte foot process effacement, or pathologically advanced markers. However, the haplotype, composed of rs1736936 and rs2735022, showed a significant association with the susceptibility to develop childhood IgAN (haplotype T/C: dominant model, P=0.049; haplotype C/T: recessive model, P =0.030).
: Our results indicate that rs1736936 and rs2735022 as the HLA-G gene promoter haplotype might be associated with the susceptibility to develop childhood IgAN in the Korean population.
Key Words: HLA-G, Polymorphism, IgA nephropathy, Childhood

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