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A case of paraneoplastic limbic encephalitis due to ovarian mature teratoma

Korean Journal of Pediatrics 2010;53(4):603-606.
Published online April 15, 2010.
A case of paraneoplastic limbic encephalitis due to ovarian mature teratoma
Seong Heon Kim, hye Young Kim, Young Tak Im, Sang Ook Nam, Young Mi Kim
Department of Pediatrics, Pusan National University Hospital, Pusan National University College of Medicine, Busan, Korea
성숙 난소기형종에 동반된 부신생물 변연계뇌염 1례
김성헌, 김혜영, 임영탁, 남상욱, 김영미
부산대학교 의학전문대학원 소아과학교실
Correspondence: 
Young Mi Kim, Email: pink2129@naver.com
Abstract
Paraneoplastic limbic encephalitis, a remote effect of cancer without nervous system metastasis, is rare, especially in childhood. Here, we report a case of paraneoplastic limbic encephalitis associated with an ovarian mature teratoma in an adolescent girl. The 15-year-old girl developed neuropsychiatric symptoms, memory loss, seizures, and unconsciousness. Cerebrospinal fluid analysis and brain magnetic resonance imaging (MRI) findings were normal, while single photon emission computed tomography imaging showed hypoperfusion in both temporal lobes. Ultrasound and MRI of the abdomen revealed a left ovarian cystic mass. The patient experienced a significant recovery of cognitive function after surgical resection of the tumor, which was pathologically identified as a mature ovarian teratoma, and treatment with intravenous immunoglobulin.
Key Words: Paraneoplastic limbic encephalitis, Teratoma, Adolescent


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