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A case of nephrogenic diabetes insipidus due to vesicoureteral reflux.

Journal of the Korean Pediatric Society 1991;34(9):1299-1304.
Published online September 30, 1991.
A case of nephrogenic diabetes insipidus due to vesicoureteral reflux.
Yong Bae Suh, Jong Yul Jeon, Sung Ho Cha, Byoung Soo Cho, Chang Il Ahn
Department of Pediatrics, College of Medicine, Kyung Hee University, Seoul, Korea
방광요관역류에 의한 신성요붕증 1례
서용배, 전종율, 차성호, 조병수, 안창일
경희대학교 의과대학 소아과학교실
Received: 11 March 1991   • Accepted: 31 May 1991
Nephrogenic diabetes insipidus is a disorder characterized by polydipsia and polyuria resulting from failure of the renal tubules and collecting ducts to respond to antidiuretic hormone despite elevated blood levels of antidiuretic hormone. We experienced a case of nephrogenic diabetes insipidus in 13 months-old girl probably secondary to vesicoureteral reflux grade IV. The clinical manifestations were extreme thirst, polydipsia and polyuria. Family history was nonspecific and laboratory findings revealed urinary concentration defect by water deprivation test and pitressin test. But urinalysis revealed normal specific gravity. Vesicoureteral reflux was corrected by ureteroneocystostomy. In conclusion, when patient complaints of polydipsia and polyuria, water deprivation test and pitressin test are mandatory even urinary specific gravity is within normal limit.
Key Words: Nephrogenic diabetes insipidus, Vesicoureteral reflux, Urinary tract infection

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