| Early detection of gentamicin nephrotoxicity using urinary beta2-microglobulin in neonates. |
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Mi Kyung Kim1, Seung Joo Lee2 |
1Department of Pediatrics, Dong Boo City Hospital, Seoul, Korea
2Department of Pediatrics, College of Medicine, Ewha Womans University, Seoul, Korea |
| 신생아에 있어서 뇨 β2-Microglobulin을 이용한
Gentamicin 신독성의 조기발견에 대한 연구 |
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김미경1, 이승주2 |
1서울 시립 동부병원 소아과
2이화대학교 의과대학 소아과학교실 |
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Received: 16 August 1990 • Accepted: 24 October 1990 |
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| Abstract |
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Gentamicin, commonly used antibiotics in neonatal care, has a nephrotoxicity, but it is difficulto to
assess renal function in early stage.
This study evaluated the renal function and urinary β2-microglobulin excretion in 17 gentamicin
treated and 11 control neonates.
The results are as follows.
1) Urinary 02-M in gentamicin treated neonates were 0.84±0.17mg/L at postnatal day 1 and
increased to 5.99±1.15mg/L at day 4, 14.17±2.39mg/L at day 7 (r=0.697, p<0.01), which were
significantly higher than control values at postnatal day 4 and 7 (p<0.01).
2) Urinary creatinine were not significant in both groups.
3) Urinary ^-M/urinary creatinine ratio were increased by postnatal days and values at postnatal
day 7 was significantly higher than control valuse (p<0.01).
4) Serum creatinine were decreased with postnatal days, but which were not significant in both
groups.
5) Creatinine clearance were not significant in both groups.
6) FENa were not significant in both groups.
7) Urinary β2-M was not correlated with creatinine clearance or serum creatinine.
From these results, the level of urinary β2-M is a valuable laboratory aid in the early detection of
neophrotoxicity in neonates. |
| Key Words:
b2-Microglobulin, gentamicin, Nephrotoxicity |
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