Warning: fopen(/home/virtual/pediatrics/journal/upload/ip_log/ip_log_2024-03.txt) [function.fopen]: failed to open stream: Permission denied in /home/virtual/pediatrics/journal/ip_info/view_data.php on line 82

Warning: fwrite(): supplied argument is not a valid stream resource in /home/virtual/pediatrics/journal/ip_info/view_data.php on line 83
Effect of immune globulin on the prevention of coronary artery aneurysm in Kawasaki disease.

Journal of the Korean Pediatric Society 1991;34(5):668-676.
Published online May 31, 1991.
Effect of immune globulin on the prevention of coronary artery aneurysm in Kawasaki disease.
Mi Jin Jung, Chung Il Noh, Jung Yun Choi, Yong Soo Yun
Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea
Kawasaki 증후군의 관상동맥류 발생에 미치는 면역 글로불린의 효과에 대한 연구 - 2.0g/kg/day의 단일 용법의 비교 -
정미진, 노정일, 최정연, 윤용수
서울대학교 의과대학 소아과학교실
Received: 11 September 1990   • Accepted: 29 November 1990
Abstract
We compared the efficacy of each modality of treatment group in reducing the frequency of coronary artery aneurysm in children with Kawasaki syndrome. Group 1 (26 cases)-aspirin alone: Group 2 (26 cases)-intravenous gamma globulin, 400 mg per kilogram of body weight per day for five consecutive days, plus aspirin; Group 3 (21 cases)-intravenous gamma globulin, single dose of 2.0 g per kilogram of body weight per day, plus aspirin. There was no significant intergroup differences in age, sex ratio, but the duration of disease until the start of treatment and the total duration of fever were long significantly in Group 1 compared with other groups. The evaluation of coronary artery abnormalities was done by two dimensional echocardiograms. About two weeks after onset of disease, coronary artery aneurysms were present in 10 of 26 children (38.5 percent) in Group 1, 5 of 26 children (19.2 percent) in Group 2, and 4 of 21 children (19.0 percent) in Group 3 (Gri-Gr2, GrrGr3:0.1 < P < 0.25, Gr2-Gr3:1.0
Key Words: Kawasaki Disease, Coronary Artery Aneuysm, Immune Globulin, Single Dose


METRICS Graph View
  • 1,084 View
  • 14 Download