| Effect of immune globulin on the prevention of coronary artery aneurysm in Kawasaki disease. |
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Mi Jin Jung, Chung Il Noh, Jung Yun Choi, Yong Soo Yun |
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Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea |
| Kawasaki 증후군의 관상동맥류 발생에 미치는
면역 글로불린의 효과에 대한 연구
- 2.0g/kg/day의 단일 용법의 비교 - |
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정미진, 노정일, 최정연, 윤용수 |
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서울대학교 의과대학 소아과학교실 |
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Received: 11 September 1990 • Accepted: 29 November 1990 |
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| Abstract |
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We compared the efficacy of each modality of treatment group in reducing the frequency of
coronary artery aneurysm in children with Kawasaki syndrome. Group 1 (26 cases)-aspirin alone:
Group 2 (26 cases)-intravenous gamma globulin, 400 mg per kilogram of body weight per day for five
consecutive days, plus aspirin; Group 3 (21 cases)-intravenous gamma globulin, single dose of 2.0 g per
kilogram of body weight per day, plus aspirin.
There was no significant intergroup differences in age, sex ratio, but the duration of disease until
the start of treatment and the total duration of fever were long significantly in Group 1 compared
with other groups. The evaluation of coronary artery abnormalities was done by two dimensional
echocardiograms. About two weeks after onset of disease, coronary artery aneurysms were present
in 10 of 26 children (38.5 percent) in Group 1, 5 of 26 children (19.2 percent) in Group 2, and 4 of 21
children (19.0 percent) in Group 3 (Gri-Gr2, GrrGr3:0.1 < P < 0.25, Gr2-Gr3:1.0
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| Key Words:
Kawasaki Disease, Coronary Artery Aneuysm, Immune Globulin, Single Dose |
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