| Changes of immune indices in children with recurrent gross hematuria (IgA nephropathy and non-IgA nephropathy) and Henoch-Schonlein purpura nephritis. |
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Seong Mi Kim1, Myung Chul Hyun1, Cheol Woo Ko1, Ja Hoon Koo1, Doo Hong Ahn1, Jung Sik Kwack2 |
1Department of Pediatrics, School of Medicine, Kyungpook National University, Taegu, Korea
2Department of Pathology, School of Medicine, Kyungpook National University, Taegu, Korea |
| 반복성 혈뇨(lgA 신병증 및 non-IgA 신병증)와
Henoch-schonlein 신염의 면역지표의 변동에 관하여 |
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김승미1, 현명철1, 고철우1, 구자훈1, 안두홍1, 곽정식2 |
1경북대학교 의과대학 소아과학교실
2경북대학교 의과대학 병리학교실 |
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Received: 23 January 1991 • Accepted: 20 February 1991 |
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| Abstract |
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A Prospective study was conducted to see the changes of immune system in recurrent gross
hematuria (IgA nephropathy and non-IgA nephropathy) and HSP nephritis in children. Study patients
consisted of 60 children with recurrent gross hematuria and Henoch-schdnlein purpura nephritis (8
IgA nephropathy, 24 non-IgA nephropathy and 28 HSP nephritis). The cellular immune indices (total
T, T4, T8 cells and T4/T8 ratio) and humoral immune indices (IgG, A, M and E) were measured
during the hematuric and non-hematuric period. Following results were obtained.
The proportion of T4 cells of peripheral blood during the hematuric period of patients with IgA
nephropathy rose to 35.4±14.9% from the non-hematuric value of 20.0士9.1%. The T4/T8 ratio
during hematuric period of patients with IgA nephropathy rose to 1.51±0.77 from non-hematuric
valus of 0.73±0.33. The values of serum IgA and IgE during hematuric period of patients with IgA
nephropathy rose to 237 ±106 mg/dl, 231 ±226 IU/dl from non-hematuric values of 140 ±10, 28±23,
respectively. These changes of cellular and humoral immune indices showed statistically significant
differences(p < 0.05). However, these changes were not found in patients with non-IgA nephropathy
nor HSP nephritis.
In conclusion, it can be said that the immune mechanism involved in IgA nephropathy is different
from that of HSP nephritis. |
| Key Words:
IgA nephropathy, Henoch-schonlein purpura nephritis, Immune index |
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