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IgA Nephropathy in Childhood.

Journal of the Korean Pediatric Society 1990;33(9):1237-1243.
Published online September 30, 1990.
IgA Nephropathy in Childhood.
Yong Choi1, Dong Woo Son1, Ja Wook Koo1, Dong Kyu Jin1, Hae Il Cheong1, Kwang Wook Ko1, Hyun Soon Lee2, Yong Il Kim2
1Departments of Pediatrics, Seoul National University College of Medicine, Seoul, Korea
2Department of Pathology, Seoul National University College of Medicine, Seoul, Korea
소아에서의 IgA 신장염 - Nephrotic Range Proteinuria의 임상적 의의 -
최용1, 손동우1, 구자욱1, 진동규1, 정해일1, 고광욱1, 이현순2, 김용일2
1서울대학교 의과대학 소아과학교실
2서울대학교 의과대학 병리학교실
Received: 3 April 1990   • Accepted: 22 June 1990
In this study we compared between the patients with recurrent gross hematuria (group 1, n=45) and * with nephrotic range proteinuria (group 2, n=21) in IgA nephropathy who were admitted to Seoul National University Children’s Hospital during the period from January, 1980 to December, 1989. The results of the study were as follows. 1) Age of onset and sex ratio were not different between the groups. 2) Incidences of elevated serum creatinine and hypertension were also not different between the groups. All the above patients except 1 in group 1 showed only transient abnormalities. 3) Serum IgA level was significantly (p<0.01) higher in the group 1 than the group 2. In the group 1, 34.1% showed the serum IgA higher than 350 mg/dl. 4) Pathologically the group 2 patients showed more severe abnormalities than the group 1 accord- ing to Meadow classification. Acute pathological lesions such as cellular proliferation and cellular crescents were more common and severe in group 2, however percent of involvement of glomerular sclerosis which thought to be chronic lesion was not different between the groups. 5) During the period of follow up, 31% in group 1 and 38% in group 2 showed normal urinalysis respectively which were not different statistically. However 6 out of 21 nephrotic range proteinuria patients showed persistent severe proteinuria. With the above results we concluded that nephrotic range proteinuria in early period of IgA nephropathy in children may not necessarily mean poor prognostic sign.
Key Words: IgA nephropthy, Recurrent gross hematuria, Nephrotic range proteinuria

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