The Effect of Low-Dosage Alpha-Interferon Therapy in Children with Chronic Active Hepatitis B. |
Hee Kyung Kim, Sung Min Choi, Cheol Woo Ko, Kun Soo Lee, Ja Hoon Koo, Doo Hong Ahn |
Department of Pediatrics, College of Medicine, Kyungpook National University, Taegu, Korea |
소아의 B형 만성활동성간염에 대한 Low-Dosage
Alpha Interferon의 치료 효과 |
김희경, 최성민, 고철우, 이건수, 구자훈, 안두홍 |
경북대학교 의과대학 소아과학교실 |
Received: 27 February 1990 • Accepted: 20 March 1990 |
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Abstract |
A clinical trial was conducted to determine the effect of low-dosage recombinant a-interferon
therapy in children with HBs Ag and HBe Ag positive chronic active hepatitis. Studied patients
consist of 7 biopsy-proven children (aged 6.5-11.5 yr). After 16 weeks of therapy, following results
were obtained.
Out of 7 HBe Ag positive cases, 5 cases (71.4%) were converted to HBe Ag negative state. One of
two HBV-DNA positive cases was converted to HBV-DNA negative and the other one showed
decreased in titer. None showed any change of HBs Antigenecity. Six patients who had high level of
serum transaminase before therapy showed normal range levels after completion of therapy. Cellular
immune indices (total T, T4, T8 cells and T4/T8 ratio) before therapy showed decreased total T,
increased T4, decreased T8 cells and increased T4/T8 ratio. These changes of cellular immune indices
were statistically significant compared to control. (p<0.05)
In summary, it can be said that short-term effect of recombinant a-interferon therapy in children
with chronic active hepatitis B was excellent. However, longterm effect of this therapy shoud be
evaluated on more prolonged period of time. |
Key Words:
Chronic Active Hepatitis B, Alpha-Interferon |
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