| The Change of Anti-HBs Titer after Hepatitis B Vaccination in Newborn. |
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Ji Hye Kang, Young Mi Hong, Seung Joo Lee |
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Department of Pediatrics, Ewha Womans University, College of Medicine, Seoul, Korea |
| B형 간염 예방접종 후 항체가 변화에 관한 연구 |
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강지혜, 홍영미, 이승주 |
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이화대학교 의과대학 소아과학교실 |
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Received: 29 September 1989 • Accepted: 15 November 1989 |
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| Abstract |
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Hepatitis B vaccination is an accepted preventive measure for all newborn as well as the risk
group. However, there is some uncertainty about the persistence of anti-HBs and the timing of
booster vaccination.
We studied anti-HBs titer, positive rate and minimum protective rate in relation to time interval
after the third vaccination in 102 infants bom to HBsAg negative mother (Group I) and 52 infants
bom to HBsAg positive mother (Group II) from July, 1984 to December 1988.
The results were as follows.
1) HBsAg was positive in 3% of 9392 pregnant woman
2) The titer of anti-HBs decreased significantly in relation to time interval after the third vaccina-
tion. (p<0.05)
3) No significant difference in the mean anti-HBs titer, positive rate and minimum protective rate
in relation to time interval between two groups suggested no effect of maternal HBsAg on the
antibody response of offspring.
4) Anti-HBs positive rate and minimum protective rate were 98.4% and 85.2%, respectively in 1-12
rrwnths，but decreased rapidly after 36 months, to 68.4% and 47.4% in 37-48 months. |
| Key Words:
Hepatitis B, Hepatitis vaccination on Newborn |
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