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Prognosis according to Etiology and Age at Diagnosis in Congenital Hypothyroidism.

Journal of the Korean Pediatric Society 1990;33(4):506-513.
Published online April 30, 1990.
Prognosis according to Etiology and Age at Diagnosis in Congenital Hypothyroidism.
Myoung Sook Nam1, Young Jong Oh1, Byung Hee Kim2, Young Jong Woo2, Young Youn Choi2, Tai Ju Hwang2
1Department of Pediatrics, St. Columban "s Hospital, Mokpo, Korea
2Department of Pediatrics, Chonnam University Hospital, Kwang Ju, Korea
선천성 갑상선 기능저하증의 원인과 진단시기에 따른 예후
남명숙1, 오영종1, 김병희2, 우영종2, 최영륜2, 황태주2
1목포 성골롬반병원 소아과
2전남대학교 의과대학 소아과학교실
Received: 24 June 1989   • Accepted: 28 September 1989
A retrospective study on patients with congenital hypothyroidism was undertaken. The following
were obtained from 17 patients, on whom follow up investigations were available. 1) Males outnumbered females. The etiologic classification revealed: thyroid agenesis (64.7%), dyshormonogenesis (23.5%), and ectopic thyroid (11.8%). 2) In two-thirds of cases the diagnosis were made under 1 year of age, with 23.5% of cases being diagnoses below 3 month and 41.2% between 4 to 12 month. The mean age at initial diagnosis was 1.2 year for thyroid agenesis, 2.7 year for dyshormonogenesis, and 8.5 year for ectopic thyroid. 3) Compared to the chronological age, both bone age (in 100%) and height age (in 70.6%) were below the 3rd percentiles. 4) Thyroid hormone study at initial diagnosis revealed that TSH was increased in all cases but the least in ectopic thyroid. Mean T in ectopic thyroid and T3 in dyshormonogenesis and ectopic thyroid were normal limits. 5) 4 in 11 cases of thyroid agenesis, 3 in 4 cases of ectopic thyroid had intelligence guotient (IQ) above 75 by modified Goodenough- Harris Drawing test. 6) Higher IQ values were anticip ated in the cases with higher T3 values or with lower TSH values at initial diagnosis.
Key Words: Congenital hypothyroidism, TSH, T3, T4, Intelligence quotient

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