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Effects of long-term anticonvulsant therapy of thyroid function.

Journal of the Korean Pediatric Society 1989;32(11):1533-1539.
Published online November 30, 1989.
Effects of long-term anticonvulsant therapy of thyroid function.
Sei Joong Ko, Duk Hi Kim, Chang Jun Coe
Department of Pediatrics, Yonsei University Medical College, Seoul, Korea
항경련제의 장기투여가 갑상선 기능에 마치는 영향
고세중, 김덕희, 고창준
연세대학교 의과대학 소아과학교실
Received: 13 July 1989   • Accepted: 13 July 1989
Serum concentrations of total triiodothyronine (T3) and thyroxine (T4) as well as serum thyroid- stimulating hormone (TSH) were measured in 108 patients with childhood epilepsy taking anticonvul- sants and in 54 normal healthy children as control group. Of these 108 patients, 23 were treated with carbamazepine alone, 17 were phenytoin alone and the rest 68 were treated with combination of two or more drugs involving carbamazepine and phenytoin. The T4 and the TSH concentrations were depressed in anticonvulsant treated group, and the degree of the decrease was more severe in a group who had combination therapy with carbamazepine and phenytoin. And as for the treatment duration, the degrees of the decrease of the T4 and the TSH were most markedly observed in more than 5 year treatment group. There was no significant decrease in serum T3 concentration in any treatment group. The possible mechanisms of the influence of anticonvulsants on thyroid function were discussed. It is thought that thyroid function test would be needed during long-term anticonvulsant therapy.
Key Words: Anticonvulsant drug, Thyroid function

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