| A Study of Milk β-Glucuronidase Activity in Breast Milk Associating with Neonatal Jaundice. |
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Soo Chun Kim, Chong Woo Bae, Yong Mook Choi, Chang Il Ahn |
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Department of Pediatrics, College of Medicine, Kyung Hee University, Seoul, Korea |
| 신생아 모유성황달에서 모유내 β-Glucuronidase
활성도에 관한 연구 |
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김수천, 배종우, 최용묵, 안창일 |
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경희대학교 의과대학 소아과학교실 |
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Received: 20 February 1989 • Accepted: 20 April 1989 |
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| Abstract |
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Since the 1960s, several reports have been presented to explain how the ingestion of human milk is
related to neonatal jaundice. Recently, the jaundiced neonates whose mother’s milk contain sub-
stances (eg, pregnane 3a, 20β-diol, lipoprotein lipase, free fatty acid, β-glucuronidase etc) facilitating
the reabsorption of unconjugated bilirubin in the neonatal intestine through the enhancement of the
enterohepatic circulation, were called the breast milk jaundice syndrome.
To evaluate the relation between the effect of β-glucuronidase activity in maternal milk and the
appearance of breast milk jaundice, this study were undertaken.
The β-glucuronidase activity in breast milk was measured in 50 cases of breast milk jaundice group
(study group) and 53 cases of normal control group along with serum bilirubin concentration in breast
milk jaundice group.
The results were as follows;
1) In breast milk jaundice group, the peak total bilirubin concentration was 15.0-19.9 mg/dl which
was most common (20 cases, 40.0%).
2) In breast milk jaundice gorup, the appearance of peak serum bilirubin concentration was the age
group of 7 to 13 days of life which was most common.
3) Average enzymatic activity of ^-glucuronidase was 10.64 ±6.76 n mole/ml in breast milk jaun-
dice gorup, whereas it was 6.25 ±4.23 n mole/min/ml in control group. So this enzymatic activity in
breast milk jaundice group is significantt, statistically (p< 0.001).
4) The relationship betweeen increase of total bilirubin concentration in neonates and increase of
β-glucuronidase activity in maternal milk was not significant, statistically (p>0.05).
Therefore, it is suggested that β-glucuronidase play a role of developing jaundice in breast milk
jaundiced neonates. |
| Key Words:
β-Glucuronidase, Breast milk jaundice, Hyperbilirubinemia of newborn |
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